Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation

Gye Young Park; Yong Gyu Lee; Evgeny Berdyshev; Sharmilee Nyenhuis; Jian Du; Panfeng Fu; Irina A. Gorshkova; Yongchao Li; Sangwoon Chung; Manjula Karpurapu; Jing Deng; Ravi Ranjan; Lei Xiao; H. Ari Jaffe; Susan J. Corbridge; Elizabeth A.B. Kelly; Nizar N. Jarjour; Jerold Chun; Glenn D. Prestwich; Eleanna Kaffe; Ioanna Ninou; Vassilis Aidinis; Andrew J. Morris; Susan S. Smyth; Steven J. Ackerman; Viswanathan Natarajan; John W. Christman

doi:10.1164/rccm.201306-1014OC

Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation

Gye Young Park, Yong Gyu Lee, Evgeny Berdyshev, Sharmilee Nyenhuis, Jian Du, Panfeng Fu, Irina A. Gorshkova, Yongchao Li, Sangwoon Chung, Manjula Karpurapu, Jing Deng, Ravi Ranjan, Lei Xiao, H. Ari Jaffe, Susan J. Corbridge, Elizabeth A.B. Kelly, Nizar N. Jarjour, Jerold Chun, Glenn D. Prestwich, Eleanna KaffeIoanna Ninou, Vassilis Aidinis, Andrew J. Morris, Susan S. Smyth, Steven J. Ackerman, Viswanathan Natarajan, John W. Christman

Internal Medicine

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

Rationale: Bioactive lipid mediators, derived from membrane lipid precursors, are released into the airway and airspace where they bind high-affinity cognate receptors and may mediate asthma pathogenesis. Lysophosphatidic acid (LPA), a bioactive lipid mediator generated by the enzymatic activity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an array of biological actions on cell proliferation, migration, survival, differentiation, and motility, and therefore could mediate asthma pathogenesis.

Original language	English
Pages (from-to)	928-940
Number of pages	13
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	188
Issue number	8
DOIs	https://doi.org/10.1164/rccm.201306-1014OC
State	Published - Oct 15 2013

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine

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Park, G. Y., Lee, Y. G., Berdyshev, E., Nyenhuis, S., Du, J., Fu, P., Gorshkova, I. A., Li, Y., Chung, S., Karpurapu, M., Deng, J., Ranjan, R., Xiao, L., Jaffe, H. A., Corbridge, S. J., Kelly, E. A. B., Jarjour, N. N., Chun, J., Prestwich, G. D., ... Christman, J. W. (2013). Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation. American Journal of Respiratory and Critical Care Medicine, 188(8), 928-940. https://doi.org/10.1164/rccm.201306-1014OC

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title = "Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation",

abstract = "Rationale: Bioactive lipid mediators, derived from membrane lipid precursors, are released into the airway and airspace where they bind high-affinity cognate receptors and may mediate asthma pathogenesis. Lysophosphatidic acid (LPA), a bioactive lipid mediator generated by the enzymatic activity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an array of biological actions on cell proliferation, migration, survival, differentiation, and motility, and therefore could mediate asthma pathogenesis.",

author = "Park, {Gye Young} and Lee, {Yong Gyu} and Evgeny Berdyshev and Sharmilee Nyenhuis and Jian Du and Panfeng Fu and Gorshkova, {Irina A.} and Yongchao Li and Sangwoon Chung and Manjula Karpurapu and Jing Deng and Ravi Ranjan and Lei Xiao and Jaffe, {H. Ari} and Corbridge, {Susan J.} and Kelly, {Elizabeth A.B.} and Jarjour, {Nizar N.} and Jerold Chun and Prestwich, {Glenn D.} and Eleanna Kaffe and Ioanna Ninou and Vassilis Aidinis and Morris, {Andrew J.} and Smyth, {Susan S.} and Ackerman, {Steven J.} and Viswanathan Natarajan and Christman, {John W.}",

year = "2013",

month = oct,

day = "15",

doi = "10.1164/rccm.201306-1014OC",

language = "English",

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pages = "928--940",

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Park, GY, Lee, YG, Berdyshev, E, Nyenhuis, S, Du, J, Fu, P, Gorshkova, IA, Li, Y, Chung, S, Karpurapu, M, Deng, J, Ranjan, R, Xiao, L, Jaffe, HA, Corbridge, SJ, Kelly, EAB, Jarjour, NN, Chun, J, Prestwich, GD, Kaffe, E, Ninou, I, Aidinis, V, Morris, AJ, Smyth, SS, Ackerman, SJ, Natarajan, V & Christman, JW 2013, 'Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation', American Journal of Respiratory and Critical Care Medicine, vol. 188, no. 8, pp. 928-940. https://doi.org/10.1164/rccm.201306-1014OC

TY - JOUR

T1 - Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation

AU - Park, Gye Young

AU - Lee, Yong Gyu

AU - Berdyshev, Evgeny

AU - Nyenhuis, Sharmilee

AU - Du, Jian

AU - Fu, Panfeng

AU - Gorshkova, Irina A.

AU - Li, Yongchao

AU - Chung, Sangwoon

AU - Karpurapu, Manjula

AU - Deng, Jing

AU - Ranjan, Ravi

AU - Xiao, Lei

AU - Jaffe, H. Ari

AU - Corbridge, Susan J.

AU - Kelly, Elizabeth A.B.

AU - Jarjour, Nizar N.

AU - Chun, Jerold

AU - Prestwich, Glenn D.

AU - Kaffe, Eleanna

AU - Ninou, Ioanna

AU - Aidinis, Vassilis

AU - Morris, Andrew J.

AU - Smyth, Susan S.

AU - Ackerman, Steven J.

AU - Natarajan, Viswanathan

AU - Christman, John W.

PY - 2013/10/15

Y1 - 2013/10/15

N2 - Rationale: Bioactive lipid mediators, derived from membrane lipid precursors, are released into the airway and airspace where they bind high-affinity cognate receptors and may mediate asthma pathogenesis. Lysophosphatidic acid (LPA), a bioactive lipid mediator generated by the enzymatic activity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an array of biological actions on cell proliferation, migration, survival, differentiation, and motility, and therefore could mediate asthma pathogenesis.

AB - Rationale: Bioactive lipid mediators, derived from membrane lipid precursors, are released into the airway and airspace where they bind high-affinity cognate receptors and may mediate asthma pathogenesis. Lysophosphatidic acid (LPA), a bioactive lipid mediator generated by the enzymatic activity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an array of biological actions on cell proliferation, migration, survival, differentiation, and motility, and therefore could mediate asthma pathogenesis.

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Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation

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