Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation

Gye Young Park, Yong Gyu Lee, Evgeny Berdyshev, Sharmilee Nyenhuis, Jian Du, Panfeng Fu, Irina A. Gorshkova, Yongchao Li, Sangwoon Chung, Manjula Karpurapu, Jing Deng, Ravi Ranjan, Lei Xiao, H. Ari Jaffe, Susan J. Corbridge, Elizabeth A.B. Kelly, Nizar N. Jarjour, Jerold Chun, Glenn D. Prestwich, Eleanna KaffeIoanna Ninou, Vassilis Aidinis, Andrew J. Morris, Susan S. Smyth, Steven J. Ackerman, Viswanathan Natarajan, John W. Christman

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

Rationale: Bioactive lipid mediators, derived from membrane lipid precursors, are released into the airway and airspace where they bind high-affinity cognate receptors and may mediate asthma pathogenesis. Lysophosphatidic acid (LPA), a bioactive lipid mediator generated by the enzymatic activity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an array of biological actions on cell proliferation, migration, survival, differentiation, and motility, and therefore could mediate asthma pathogenesis.

Original languageEnglish
Pages (from-to)928-940
Number of pages13
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume188
Issue number8
DOIs
StatePublished - Oct 15 2013

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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