TY - JOUR
T1 - Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation
AU - Park, Gye Young
AU - Lee, Yong Gyu
AU - Berdyshev, Evgeny
AU - Nyenhuis, Sharmilee
AU - Du, Jian
AU - Fu, Panfeng
AU - Gorshkova, Irina A.
AU - Li, Yongchao
AU - Chung, Sangwoon
AU - Karpurapu, Manjula
AU - Deng, Jing
AU - Ranjan, Ravi
AU - Xiao, Lei
AU - Jaffe, H. Ari
AU - Corbridge, Susan J.
AU - Kelly, Elizabeth A.B.
AU - Jarjour, Nizar N.
AU - Chun, Jerold
AU - Prestwich, Glenn D.
AU - Kaffe, Eleanna
AU - Ninou, Ioanna
AU - Aidinis, Vassilis
AU - Morris, Andrew J.
AU - Smyth, Susan S.
AU - Ackerman, Steven J.
AU - Natarajan, Viswanathan
AU - Christman, John W.
PY - 2013/10/15
Y1 - 2013/10/15
N2 - Rationale: Bioactive lipid mediators, derived from membrane lipid precursors, are released into the airway and airspace where they bind high-affinity cognate receptors and may mediate asthma pathogenesis. Lysophosphatidic acid (LPA), a bioactive lipid mediator generated by the enzymatic activity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an array of biological actions on cell proliferation, migration, survival, differentiation, and motility, and therefore could mediate asthma pathogenesis.
AB - Rationale: Bioactive lipid mediators, derived from membrane lipid precursors, are released into the airway and airspace where they bind high-affinity cognate receptors and may mediate asthma pathogenesis. Lysophosphatidic acid (LPA), a bioactive lipid mediator generated by the enzymatic activity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an array of biological actions on cell proliferation, migration, survival, differentiation, and motility, and therefore could mediate asthma pathogenesis.
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U2 - 10.1164/rccm.201306-1014OC
DO - 10.1164/rccm.201306-1014OC
M3 - Article
C2 - 24050723
AN - SCOPUS:84886390081
SN - 1073-449X
VL - 188
SP - 928
EP - 940
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
IS - 8
ER -