Available space and extracellular transport of macromolecules: Effects of pore size and connectedness

Fan Yuan, Ave Krol, Sheng Tong

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Available space and extracellular transport of macromolecules was described. Volume fraction of dextran was found to decrease sharply in tumor tissues when the molecular weight (MW) was increased from 40,000 to 70,000. Numerical simulations revealed that the sharp decrease in volume fraction of solutes required the existence of at least two populations of pores and the lack of connectedness of available pores in the interstitial space.

Original languageEnglish
Pages (from-to)1150-1158
Number of pages9
JournalAnnals of Biomedical Engineering
Volume29
Issue number12
DOIs
StatePublished - 2001

Bibliographical note

Funding Information:
The work is supported by a grant from the Whitaker Foundation (97-0062).

Keywords

  • Diffusion
  • Drug delivery
  • Partition coefficient

ASJC Scopus subject areas

  • Biomedical Engineering

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