Abstract
Available space and extracellular transport of macromolecules was described. Volume fraction of dextran was found to decrease sharply in tumor tissues when the molecular weight (MW) was increased from 40,000 to 70,000. Numerical simulations revealed that the sharp decrease in volume fraction of solutes required the existence of at least two populations of pores and the lack of connectedness of available pores in the interstitial space.
Original language | English |
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Pages (from-to) | 1150-1158 |
Number of pages | 9 |
Journal | Annals of Biomedical Engineering |
Volume | 29 |
Issue number | 12 |
DOIs | |
State | Published - 2001 |
Bibliographical note
Funding Information:The work is supported by a grant from the Whitaker Foundation (97-0062).
Funding
The work is supported by a grant from the Whitaker Foundation (97-0062).
Funders | Funder number |
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The Whitaker Foundation | 97-0062 |
The Whitaker Foundation |
Keywords
- Diffusion
- Drug delivery
- Partition coefficient
ASJC Scopus subject areas
- Biomedical Engineering