Avobenzone incorporation in a diverse range of Ru(ii) scaffolds produces potent potential antineoplastic agents

Raphael T. Ryan; Dmytro Havrylyuk; Kimberly C. Stevens; L. Henry Moore; Doo Young Kim; Jessica S. Blackburn; David K. Heidary; John P. Selegue; Edith C. Glazer

doi:10.1039/d0dt02016h

Avobenzone incorporation in a diverse range of Ru(ii) scaffolds produces potent potential antineoplastic agents

Raphael T. Ryan, Dmytro Havrylyuk, Kimberly C. Stevens, L. Henry Moore, Doo Young Kim, Jessica S. Blackburn, David K. Heidary, John P. Selegue, Edith C. Glazer

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making them promising candidates for combined chemo-photodynamic therapy.

Original language	English
Pages (from-to)	12161-12167
Number of pages	7
Journal	Dalton Transactions
Volume	49
Issue number	35
DOIs	https://doi.org/10.1039/d0dt02016h
State	Published - Sep 21 2020

Bibliographical note

Funding Information:
We gratefully acknowledge the National Institutes of Health (Grant GM107586 to E. C. G. and DP2CA228043 to J. S. B) and the Kentucky Science & Engineering Foundation (KSEF-4003-RDE-020 to J. P. S. and E. C. G.) for the support of this research. LC MS data was obtained using an instrument kindly shared by Dr Steven Van Lanen (UKY College of Pharmacy) and supported in part by the University of Kentucky Vice President for Research.

Publisher Copyright:
© 2020 The Royal Society of Chemistry.

ASJC Scopus subject areas

Inorganic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/d0dt02016h

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title = "Avobenzone incorporation in a diverse range of Ru(ii) scaffolds produces potent potential antineoplastic agents",

abstract = "Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making them promising candidates for combined chemo-photodynamic therapy.",

author = "Ryan, {Raphael T.} and Dmytro Havrylyuk and Stevens, {Kimberly C.} and Moore, {L. Henry} and Kim, {Doo Young} and Blackburn, {Jessica S.} and Heidary, {David K.} and Selegue, {John P.} and Glazer, {Edith C.}",

note = "Funding Information: We gratefully acknowledge the National Institutes of Health (Grant GM107586 to E. C. G. and DP2CA228043 to J. S. B) and the Kentucky Science & Engineering Foundation (KSEF-4003-RDE-020 to J. P. S. and E. C. G.) for the support of this research. LC MS data was obtained using an instrument kindly shared by Dr Steven Van Lanen (UKY College of Pharmacy) and supported in part by the University of Kentucky Vice President for Research. Publisher Copyright: {\textcopyright} 2020 The Royal Society of Chemistry.",

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month = sep,

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doi = "10.1039/d0dt02016h",

language = "English",

volume = "49",

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T1 - Avobenzone incorporation in a diverse range of Ru(ii) scaffolds produces potent potential antineoplastic agents

AU - Ryan, Raphael T.

AU - Havrylyuk, Dmytro

AU - Stevens, Kimberly C.

AU - Moore, L. Henry

AU - Kim, Doo Young

AU - Blackburn, Jessica S.

AU - Heidary, David K.

AU - Selegue, John P.

AU - Glazer, Edith C.

N1 - Funding Information: We gratefully acknowledge the National Institutes of Health (Grant GM107586 to E. C. G. and DP2CA228043 to J. S. B) and the Kentucky Science & Engineering Foundation (KSEF-4003-RDE-020 to J. P. S. and E. C. G.) for the support of this research. LC MS data was obtained using an instrument kindly shared by Dr Steven Van Lanen (UKY College of Pharmacy) and supported in part by the University of Kentucky Vice President for Research. Publisher Copyright: © 2020 The Royal Society of Chemistry.

PY - 2020/9/21

Y1 - 2020/9/21

N2 - Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making them promising candidates for combined chemo-photodynamic therapy.

AB - Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making them promising candidates for combined chemo-photodynamic therapy.

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Avobenzone incorporation in a diverse range of Ru(ii) scaffolds produces potent potential antineoplastic agents

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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