Avobenzone incorporation in a diverse range of Ru(ii) scaffolds produces potent potential antineoplastic agents

Raphael T. Ryan, Dmytro Havrylyuk, Kimberly C. Stevens, L. Henry Moore, Doo Young Kim, Jessica S. Blackburn, David K. Heidary, John P. Selegue, Edith C. Glazer

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making them promising candidates for combined chemo-photodynamic therapy.

Original languageEnglish
Pages (from-to)12161-12167
Number of pages7
JournalDalton Transactions
Volume49
Issue number35
DOIs
StatePublished - Sep 21 2020

Bibliographical note

Publisher Copyright:
© 2020 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Inorganic Chemistry

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