Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making them promising candidates for combined chemo-photodynamic therapy.
|Number of pages||7|
|State||Published - Sep 21 2020|
Bibliographical noteFunding Information:
We gratefully acknowledge the National Institutes of Health (Grant GM107586 to E. C. G. and DP2CA228043 to J. S. B) and the Kentucky Science & Engineering Foundation (KSEF-4003-RDE-020 to J. P. S. and E. C. G.) for the support of this research. LC MS data was obtained using an instrument kindly shared by Dr Steven Van Lanen (UKY College of Pharmacy) and supported in part by the University of Kentucky Vice President for Research.
© 2020 The Royal Society of Chemistry.
ASJC Scopus subject areas
- Inorganic Chemistry