Axon plasticity in the mammalian central nervous system after injury

Meifan Chen, Binhai Zheng

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


It is widely recognized that severed axons in the adult central nervous system (CNS) have limited capacity to regenerate. However, mounting evidence from studies of CNS injury response and repair is challenging the prevalent view that the adult mammalian CNS is incapable of structural reorganization to adapt to an altered environment. Animal studies demonstrate the potential to achieve significant anatomical repair and functional recovery following CNS injury by manipulating axon growth regulators alone or in combination with activity-dependent strategies. With a growing understanding of the cellular and molecular mechanisms regulating axon plasticity, and the availability of new experimental tools to map detour circuits of functional importance, directing circuit rewiring to promote functional recovery may be achieved.

Original languageEnglish
Pages (from-to)583-593
Number of pages11
JournalTrends in Neurosciences
Issue number10
StatePublished - Oct 1 2014

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Ltd.

ASJC Scopus subject areas

  • General Neuroscience


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