B lymphocyte development, heterogeneity, and function

W. E. Paul; I. Scher; J. J. Mond; A. A. Ahmed; B. Subbarao; D. E. Mosier

doi:10.1002/art.1780210929

B lymphocyte development, heterogeneity, and function

W. E. Paul, I. Scher, J. J. Mond, A. A. Ahmed, B. Subbarao, D. E. Mosier

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Abstract

Thymus‐independent (B) lymphocytes are a heterogeneous group of cells which, it is increasingly clear, undergo an ordered sequence of differentiation steps from stem cells to antibody producing cells. Through the study of the immunologic potential of B lymphocytes from neonatal mice and from mice with an X‐linked immune defect, it has become possible to assign certain functions to cells of distinct differentiated states. Furthermore, a differentiation antigen, Lyb 5, has been identified which acts as a marker of a particular subset of B lymphocytes in normal mice. Initial studies of the functional properties of Lyb 5⁺ and Lyb 5⁻ B lymphocytes are described.

Original language	English
Pages (from-to)	S174-S179
Journal	Arthritis and Rheumatism
Volume	21
Issue number	1 S
DOIs	https://doi.org/10.1002/art.1780210929
State	Published - Jun 1978

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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AU - Paul, W. E.

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AU - Mond, J. J.

AU - Ahmed, A. A.

AU - Subbarao, B.

AU - Mosier, D. E.

PY - 1978/6

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AB - Thymus‐independent (B) lymphocytes are a heterogeneous group of cells which, it is increasingly clear, undergo an ordered sequence of differentiation steps from stem cells to antibody producing cells. Through the study of the immunologic potential of B lymphocytes from neonatal mice and from mice with an X‐linked immune defect, it has become possible to assign certain functions to cells of distinct differentiated states. Furthermore, a differentiation antigen, Lyb 5, has been identified which acts as a marker of a particular subset of B lymphocytes in normal mice. Initial studies of the functional properties of Lyb 5+ and Lyb 5− B lymphocytes are described.

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B lymphocyte development, heterogeneity, and function

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