B lymphocyte development, heterogeneity, and function

W. E. Paul, I. Scher, J. J. Mond, A. A. Ahmed, B. Subbarao, D. E. Mosier

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Thymus‐independent (B) lymphocytes are a heterogeneous group of cells which, it is increasingly clear, undergo an ordered sequence of differentiation steps from stem cells to antibody producing cells. Through the study of the immunologic potential of B lymphocytes from neonatal mice and from mice with an X‐linked immune defect, it has become possible to assign certain functions to cells of distinct differentiated states. Furthermore, a differentiation antigen, Lyb 5, has been identified which acts as a marker of a particular subset of B lymphocytes in normal mice. Initial studies of the functional properties of Lyb 5+ and Lyb 5 B lymphocytes are described.

Original languageEnglish
Pages (from-to)S174-S179
JournalArthritis and Rheumatism
Volume21
Issue number1 S
DOIs
StatePublished - Jun 1978

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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