TY - JOUR
T1 - B lymphocyte development, heterogeneity, and function
AU - Paul, W. E.
AU - Scher, I.
AU - Mond, J. J.
AU - Ahmed, A. A.
AU - Subbarao, B.
AU - Mosier, D. E.
PY - 1978/6
Y1 - 1978/6
N2 - Thymus‐independent (B) lymphocytes are a heterogeneous group of cells which, it is increasingly clear, undergo an ordered sequence of differentiation steps from stem cells to antibody producing cells. Through the study of the immunologic potential of B lymphocytes from neonatal mice and from mice with an X‐linked immune defect, it has become possible to assign certain functions to cells of distinct differentiated states. Furthermore, a differentiation antigen, Lyb 5, has been identified which acts as a marker of a particular subset of B lymphocytes in normal mice. Initial studies of the functional properties of Lyb 5+ and Lyb 5− B lymphocytes are described.
AB - Thymus‐independent (B) lymphocytes are a heterogeneous group of cells which, it is increasingly clear, undergo an ordered sequence of differentiation steps from stem cells to antibody producing cells. Through the study of the immunologic potential of B lymphocytes from neonatal mice and from mice with an X‐linked immune defect, it has become possible to assign certain functions to cells of distinct differentiated states. Furthermore, a differentiation antigen, Lyb 5, has been identified which acts as a marker of a particular subset of B lymphocytes in normal mice. Initial studies of the functional properties of Lyb 5+ and Lyb 5− B lymphocytes are described.
UR - https://www.scopus.com/pages/publications/0018238851
UR - https://www.scopus.com/inward/citedby.url?scp=0018238851&partnerID=8YFLogxK
U2 - 10.1002/art.1780210929
DO - 10.1002/art.1780210929
M3 - Article
C2 - 307390
AN - SCOPUS:0018238851
SN - 0004-3591
VL - 21
SP - S174-S179
JO - Arthritis and Rheumatism
JF - Arthritis and Rheumatism
IS - 1 S
ER -