TY - JOUR
T1 - Baclofen does not protect against cerebral ischemia in rats
AU - Rosenbaum, Daniel M.
AU - Grotta, James C.
AU - Pettigrew, L. Creed
AU - Ostrow, Peter
AU - Strong, Roger
AU - Rhoades, Howard
AU - Picone, Carmela M.
AU - Grotta, Amy T.
PY - 1990/1
Y1 - 1990/1
N2 - Presynaptic release of glutamate into the extracellular compartment and activation of receptor-operated calcium channels may contribute to ischemic neuronal damage. We evaluated the effect of baclofen, a selective inhibitor of presynaptic glutamate release, on mortality, working memory, and light microscopic hippocampal and cortical damage in the four-vessel occlusion model of cerebral ischemia using 64 male Wistar rats. Baclofen (10 mg/kg i.p.) given 1 hour before and 30-60 minutes after 20 minutes of global ischemia did not lessen mortality, prevent ischemic cellular damage, or significantly improve working memory compared with no treatment We conclude that preischemic and postischemic administration of baclofen does not protect neurons from ischemic injury.
AB - Presynaptic release of glutamate into the extracellular compartment and activation of receptor-operated calcium channels may contribute to ischemic neuronal damage. We evaluated the effect of baclofen, a selective inhibitor of presynaptic glutamate release, on mortality, working memory, and light microscopic hippocampal and cortical damage in the four-vessel occlusion model of cerebral ischemia using 64 male Wistar rats. Baclofen (10 mg/kg i.p.) given 1 hour before and 30-60 minutes after 20 minutes of global ischemia did not lessen mortality, prevent ischemic cellular damage, or significantly improve working memory compared with no treatment We conclude that preischemic and postischemic administration of baclofen does not protect neurons from ischemic injury.
KW - Baclofen
KW - Cerebral ischemia
KW - Rats
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U2 - 10.1161/01.STR.21.1.138
DO - 10.1161/01.STR.21.1.138
M3 - Article
C2 - 2300981
AN - SCOPUS:0025124485
SN - 0039-2499
VL - 21
SP - 138
EP - 140
JO - Stroke
JF - Stroke
IS - 1
ER -