Baclofen does not protect against cerebral ischemia in rats

Daniel M. Rosenbaum, James C. Grotta, L. Creed Pettigrew, Peter Ostrow, Roger Strong, Howard Rhoades, Carmela M. Picone, Amy T. Grotta

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Presynaptic release of glutamate into the extracellular compartment and activation of receptor-operated calcium channels may contribute to ischemic neuronal damage. We evaluated the effect of baclofen, a selective inhibitor of presynaptic glutamate release, on mortality, working memory, and light microscopic hippocampal and cortical damage in the four-vessel occlusion model of cerebral ischemia using 64 male Wistar rats. Baclofen (10 mg/kg i.p.) given 1 hour before and 30-60 minutes after 20 minutes of global ischemia did not lessen mortality, prevent ischemic cellular damage, or significantly improve working memory compared with no treatment We conclude that preischemic and postischemic administration of baclofen does not protect neurons from ischemic injury.

Original languageEnglish
Pages (from-to)138-140
Number of pages3
Issue number1
StatePublished - Jan 1990


  • Baclofen
  • Cerebral ischemia
  • Rats

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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