TY - JOUR
T1 - Bacterial endotoxin lipopolysaccharide enhances synaptic transmission at low-output glutamatergic synapses
AU - Greenhalgh, Abigail
AU - Istas, Oscar
AU - Cooper, Robin L.
N1 - Publisher Copyright:
© 2020 Elsevier B.V. and Japan Neuroscience Society
PY - 2021/9
Y1 - 2021/9
N2 - The endotoxin lipopolysaccharides (LPS), secreted from gram-negative bacteria, has direct effects on synaptic transmission independent of systemic secondary cytokine responses. High concentration of LPS (500 μg/mL) from Serratia marcescens increased synaptic efficacy at glutamatergic low-output synapses more than for high-output synapses. Over an hour of exposure was not toxic to the preparation and continued to enhance synaptic transmission. A small but significant rapid hyperpolarization of the post-synaptic cells occurred, in addition to a slower enhancement of in the amplitude of evoked excitatory junction potentials. LPS may promote reserve pool vesicles to the readily releasable pool for low-output synapses. The action of LPS at the glutamatergic synapses of the crayfish neuromuscular junction is unique in promoting synaptic transmission as compared to other glutamatergic synapses in Drosophila and mammals, where synaptic transmission is depressed.
AB - The endotoxin lipopolysaccharides (LPS), secreted from gram-negative bacteria, has direct effects on synaptic transmission independent of systemic secondary cytokine responses. High concentration of LPS (500 μg/mL) from Serratia marcescens increased synaptic efficacy at glutamatergic low-output synapses more than for high-output synapses. Over an hour of exposure was not toxic to the preparation and continued to enhance synaptic transmission. A small but significant rapid hyperpolarization of the post-synaptic cells occurred, in addition to a slower enhancement of in the amplitude of evoked excitatory junction potentials. LPS may promote reserve pool vesicles to the readily releasable pool for low-output synapses. The action of LPS at the glutamatergic synapses of the crayfish neuromuscular junction is unique in promoting synaptic transmission as compared to other glutamatergic synapses in Drosophila and mammals, where synaptic transmission is depressed.
KW - Endotoxin
KW - Glutamate receptor
KW - Glutamatergic
KW - Lipopolysaccharide
KW - Serratia
KW - Synapse
UR - http://www.scopus.com/inward/record.url?scp=85090683844&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090683844&partnerID=8YFLogxK
U2 - 10.1016/j.neures.2020.08.008
DO - 10.1016/j.neures.2020.08.008
M3 - Article
C2 - 32987087
AN - SCOPUS:85090683844
SN - 0168-0102
VL - 170
SP - 59
EP - 65
JO - Neuroscience Research
JF - Neuroscience Research
ER -