GilOII has been unambiguously identified as the key enzyme performing the crucial C-C bond cleavage reaction responsible for the unique rearrangement of a benz[a]anthracene skeleton to the benzo[d]naphthopyranone backbone typical of the gilvocarcin-type natural anticancer antibiotics. Further investigations of this enzyme led to the isolation of a hydroxyoxepinone intermediate, leading to important conclusions regarding the cleavage mechanism.
|Number of pages||4|
|Journal||Journal of the American Chemical Society|
|State||Published - Nov 7 2012|
ASJC Scopus subject areas
- Chemistry (all)
- Colloid and Surface Chemistry