Basal expression of 35 kDa fos-related antigen in olfactory bulb

Keith R. Pennypacker, David E. Lennard, Pearlie M. Hudson, Jau S. Hong, Michael K. McMillian

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Recently, there have been a number of reports showing a long-term increased expression of fos-related antigens (fra), molecular weight of 35 kDa, after brain injury or chronic treatment of rats with various drugs. We report elevated basal levels of this transcription factor in the olfactory bulb relative to other brain regions. The expression of this protein is further enhanced in the olfactory bulb as long as 3 months after a single injection of kainate, an effect similar to that we previously observed in the hippocampus. The AP-1 DNA binding activity in olfactory bulb from kainate-treated rats contains and jun immunoreactivity suggesting that the 35 kDa fra dimerizes with jun protein, probably junD, to bind to AP-1 sites. Elevated basal levels of this transcription factor in the olfactory bulb appear to be related to the constant reinnervation and synaptogenesis which occurs in this brain region. The 35 kDa fra may be involved in long-term genomic program changes required to adapt to an altered biochemical environment.

Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalMolecular Brain Research
Volume34
Issue number1
DOIs
StatePublished - Dec 1 1995

Keywords

  • AP-1
  • DNA binding
  • Kainate
  • Neuronal plasticity
  • Transcription factor

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Fingerprint

Dive into the research topics of 'Basal expression of 35 kDa fos-related antigen in olfactory bulb'. Together they form a unique fingerprint.

Cite this