Basal forebrain magnocellular neurons stain for nerve growth factor receptor: Correlation with cholinergic cell bodies and effects of axotomy

J. E. Springer, S. Koh, M. W. Tayrien, R. Loy

Research output: Contribution to journalArticlepeer-review

170 Scopus citations

Abstract

Recent evidence has demonstrated the presence of nerve growth factor (NGF) in areas of the central nervous system characterized by cholinergic innervation. We report that a unique population of rat basal forebrain magnocellular neurons that project to the cortex and hippocampus are immunoreactive to a monoclonal antibody to the NGF receptor. Removal of target contact results in a time‐dependent loss or shrinkage of cells in the basal forebrain that stain for NGF receptor and acetylcholinesterase, suggesting that under normal conditions, basal forebrain cholinergic neurons utilize NGF for trophic support.

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalJournal of Neuroscience Research
Volume17
Issue number2
DOIs
StatePublished - 1987

Keywords

  • cholinergic neurons
  • trophic support

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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