TY - JOUR
T1 - BBA70 of borrelia burgdorferi is a novel plasminogen-binding protein
AU - Koenigs, Arno
AU - Hammerschmidt, Claudia
AU - Jutras, Brandon L.
AU - Pogoryelov, Denys
AU - Barthel, Diana
AU - Skerka, Christine
AU - Kugelstadt, Dominik
AU - Wallich, Reinhard
AU - Stevenson, Brian
AU - Zipfel, Peter F.
AU - Kraiczy, Peter
PY - 2013/8/30
Y1 - 2013/8/30
N2 - Background: Recruitment of plasminogen is important for efficient dissemination of Borrelia burgdorferi. Results: BBA70 of B. burgdorferi binds plasminogen, and following activation, bound plasmin can cleave fibrinogen and inactivate the key complement components C3b and C5. Conclusion: BBA70 is a potent plasminogen-binding protein. Significance: Investigation suggests that binding of plasminogen may aid in pathogen dissemination and inhibit bacteriolytic effects of the host complement system.
AB - Background: Recruitment of plasminogen is important for efficient dissemination of Borrelia burgdorferi. Results: BBA70 of B. burgdorferi binds plasminogen, and following activation, bound plasmin can cleave fibrinogen and inactivate the key complement components C3b and C5. Conclusion: BBA70 is a potent plasminogen-binding protein. Significance: Investigation suggests that binding of plasminogen may aid in pathogen dissemination and inhibit bacteriolytic effects of the host complement system.
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U2 - 10.1074/jbc.M112.413872
DO - 10.1074/jbc.M112.413872
M3 - Article
C2 - 23861404
AN - SCOPUS:84883439973
SN - 0021-9258
VL - 288
SP - 25229
EP - 25243
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 35
ER -