BBA70 of borrelia burgdorferi is a novel plasminogen-binding protein

Arno Koenigs; Claudia Hammerschmidt; Brandon L. Jutras; Denys Pogoryelov; Diana Barthel; Christine Skerka; Dominik Kugelstadt; Reinhard Wallich; Brian Stevenson; Peter F. Zipfel; Peter Kraiczy

doi:10.1074/jbc.M112.413872

BBA70 of borrelia burgdorferi is a novel plasminogen-binding protein

Arno Koenigs, Claudia Hammerschmidt, Brandon L. Jutras, Denys Pogoryelov, Diana Barthel, Christine Skerka, Dominik Kugelstadt, Reinhard Wallich, Brian Stevenson, Peter F. Zipfel, Peter Kraiczy

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Background: Recruitment of plasminogen is important for efficient dissemination of Borrelia burgdorferi. Results: BBA70 of B. burgdorferi binds plasminogen, and following activation, bound plasmin can cleave fibrinogen and inactivate the key complement components C3b and C5. Conclusion: BBA70 is a potent plasminogen-binding protein. Significance: Investigation suggests that binding of plasminogen may aid in pathogen dissemination and inhibit bacteriolytic effects of the host complement system.

Original language	English
Pages (from-to)	25229-25243
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	288
Issue number	35
DOIs	https://doi.org/10.1074/jbc.M112.413872
State	Published - Aug 30 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "BBA70 of borrelia burgdorferi is a novel plasminogen-binding protein",

abstract = "Background: Recruitment of plasminogen is important for efficient dissemination of Borrelia burgdorferi. Results: BBA70 of B. burgdorferi binds plasminogen, and following activation, bound plasmin can cleave fibrinogen and inactivate the key complement components C3b and C5. Conclusion: BBA70 is a potent plasminogen-binding protein. Significance: Investigation suggests that binding of plasminogen may aid in pathogen dissemination and inhibit bacteriolytic effects of the host complement system.",

author = "Arno Koenigs and Claudia Hammerschmidt and Jutras, {Brandon L.} and Denys Pogoryelov and Diana Barthel and Christine Skerka and Dominik Kugelstadt and Reinhard Wallich and Brian Stevenson and Zipfel, {Peter F.} and Peter Kraiczy",

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AU - Koenigs, Arno

AU - Hammerschmidt, Claudia

AU - Jutras, Brandon L.

AU - Pogoryelov, Denys

AU - Barthel, Diana

AU - Skerka, Christine

AU - Kugelstadt, Dominik

AU - Wallich, Reinhard

AU - Stevenson, Brian

AU - Zipfel, Peter F.

AU - Kraiczy, Peter

PY - 2013/8/30

Y1 - 2013/8/30

N2 - Background: Recruitment of plasminogen is important for efficient dissemination of Borrelia burgdorferi. Results: BBA70 of B. burgdorferi binds plasminogen, and following activation, bound plasmin can cleave fibrinogen and inactivate the key complement components C3b and C5. Conclusion: BBA70 is a potent plasminogen-binding protein. Significance: Investigation suggests that binding of plasminogen may aid in pathogen dissemination and inhibit bacteriolytic effects of the host complement system.

AB - Background: Recruitment of plasminogen is important for efficient dissemination of Borrelia burgdorferi. Results: BBA70 of B. burgdorferi binds plasminogen, and following activation, bound plasmin can cleave fibrinogen and inactivate the key complement components C3b and C5. Conclusion: BBA70 is a potent plasminogen-binding protein. Significance: Investigation suggests that binding of plasminogen may aid in pathogen dissemination and inhibit bacteriolytic effects of the host complement system.

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BBA70 of borrelia burgdorferi is a novel plasminogen-binding protein

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