BBA70 of borrelia burgdorferi is a novel plasminogen-binding protein

Arno Koenigs, Claudia Hammerschmidt, Brandon L. Jutras, Denys Pogoryelov, Diana Barthel, Christine Skerka, Dominik Kugelstadt, Reinhard Wallich, Brian Stevenson, Peter F. Zipfel, Peter Kraiczy

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Background: Recruitment of plasminogen is important for efficient dissemination of Borrelia burgdorferi. Results: BBA70 of B. burgdorferi binds plasminogen, and following activation, bound plasmin can cleave fibrinogen and inactivate the key complement components C3b and C5. Conclusion: BBA70 is a potent plasminogen-binding protein. Significance: Investigation suggests that binding of plasminogen may aid in pathogen dissemination and inhibit bacteriolytic effects of the host complement system.

Original languageEnglish
Pages (from-to)25229-25243
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number35
DOIs
StatePublished - Aug 30 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'BBA70 of borrelia burgdorferi is a novel plasminogen-binding protein'. Together they form a unique fingerprint.

Cite this