Abstract
Background: Recruitment of plasminogen is important for efficient dissemination of Borrelia burgdorferi. Results: BBA70 of B. burgdorferi binds plasminogen, and following activation, bound plasmin can cleave fibrinogen and inactivate the key complement components C3b and C5. Conclusion: BBA70 is a potent plasminogen-binding protein. Significance: Investigation suggests that binding of plasminogen may aid in pathogen dissemination and inhibit bacteriolytic effects of the host complement system.
Original language | English |
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Pages (from-to) | 25229-25243 |
Number of pages | 15 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 35 |
DOIs | |
State | Published - Aug 30 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology