Beclin 1-Vps34 complex architecture: Understanding the nuts and bolts of therapeutic targets

Deanna H. Morris, Calvin K. Yip, Yi Shi, Brian T. Chait, Qing Jun Wang

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


Autophagy is an important lysosomal degradation pathway that aids in the maintenance of cellular homeostasis by breaking down and recycling intracellular contents. Dysregulation of autophagy is linked to a growing number of human diseases. The Beclin 1-Vps34 protein-protein interaction network is critical for autophagy regulation and is therefore essential to cellular integrity. Manipulation of autophagy, in particular via modulation of the action of the Beclin 1-Vps34 complexes, is considered a promising route to combat autophagy-related diseases. Here we summarize recent findings on the core components and structural architecture of the Beclin 1-Vps34 complexes, and how these findings provide valuable insights into the molecular mechanisms that underlie the multiple functions of these complexes and for devising therapeutic strategies.

Original languageEnglish
Pages (from-to)398-426
Number of pages29
JournalFrontiers in Biology
Issue number5
StatePublished - Oct 1 2015

Bibliographical note

Publisher Copyright:
© 2015, Higher Education Press and Springer-Verlag Berlin Heidelberg.


  • Beclin 1
  • CX-MS
  • EM
  • Nrbf2
  • Vps34
  • complex
  • drug design
  • inhibitor
  • structure

ASJC Scopus subject areas

  • Biotechnology
  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Genetics


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