Bedtime doses of prazosin do not affect daytime salivary amylase markers in PTSD

William Vaughn McCall; Anilkumar Pillai; Chirayu D. Pandya; Laryssa McCloud; Jason A. Moraczewski; Liniya Tauhidul; Nagy A. Youssef; Doug Case; Peter B. Rosenquist

doi:10.1016/j.heliyon.2019.e01709

Bedtime doses of prazosin do not affect daytime salivary amylase markers in PTSD

William Vaughn McCall, Anilkumar Pillai, Chirayu D. Pandya, Laryssa McCloud, Jason A. Moraczewski, Liniya Tauhidul, Nagy A. Youssef, Doug Case, Peter B. Rosenquist

Neurosurgery

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Overactivity of the noradrenergic (NE) system within the central nervous system (CNS) has been postulated as a key pathophysiology of posttraumatic stress disorder (PTSD). The activity of the enzyme salivary α-amylase (sAA) has been proposed as an indirect measure of CNS NE activity, and sAA is elevated in PTSD. As an antagonist of the α-1 NE receptor, prazosin would be expected to alter sAA values in PTSD patients. However, given its short half-life, it is not clear whether bedtime doses would have an effect on daytime sAA. In the present study, we assayed daytime sAA in 20 suicidal PTSD patients who were randomized to prazosin versus placebo at bedtime-only, and found no effect in daytime sAA. These findings are consistent with studies showing an advantage for twice daily dosing of prazosin in PTSD.

Original language	English
Article number	e01709
Journal	Heliyon
Volume	5
Issue number	5
DOIs	https://doi.org/10.1016/j.heliyon.2019.e01709
State	Published - May 2019

Bibliographical note

Funding Information:
This project was supported by the American Foundation for Suicide Prevention ; DIG-0-087-13 .

Publisher Copyright:
© 2019

Keywords

Psychiatry

ASJC Scopus subject areas

General

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10.1016/j.heliyon.2019.e01709

Cite this

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title = "Bedtime doses of prazosin do not affect daytime salivary amylase markers in PTSD",

abstract = "Overactivity of the noradrenergic (NE) system within the central nervous system (CNS) has been postulated as a key pathophysiology of posttraumatic stress disorder (PTSD). The activity of the enzyme salivary α-amylase (sAA) has been proposed as an indirect measure of CNS NE activity, and sAA is elevated in PTSD. As an antagonist of the α-1 NE receptor, prazosin would be expected to alter sAA values in PTSD patients. However, given its short half-life, it is not clear whether bedtime doses would have an effect on daytime sAA. In the present study, we assayed daytime sAA in 20 suicidal PTSD patients who were randomized to prazosin versus placebo at bedtime-only, and found no effect in daytime sAA. These findings are consistent with studies showing an advantage for twice daily dosing of prazosin in PTSD.",

keywords = "Psychiatry",

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note = "Funding Information: This project was supported by the American Foundation for Suicide Prevention ; DIG-0-087-13 . Publisher Copyright: {\textcopyright} 2019",

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AU - McCall, William Vaughn

AU - Pillai, Anilkumar

AU - Pandya, Chirayu D.

AU - McCloud, Laryssa

AU - Moraczewski, Jason A.

AU - Tauhidul, Liniya

AU - Youssef, Nagy A.

AU - Case, Doug

AU - Rosenquist, Peter B.

PY - 2019/5

Y1 - 2019/5

N2 - Overactivity of the noradrenergic (NE) system within the central nervous system (CNS) has been postulated as a key pathophysiology of posttraumatic stress disorder (PTSD). The activity of the enzyme salivary α-amylase (sAA) has been proposed as an indirect measure of CNS NE activity, and sAA is elevated in PTSD. As an antagonist of the α-1 NE receptor, prazosin would be expected to alter sAA values in PTSD patients. However, given its short half-life, it is not clear whether bedtime doses would have an effect on daytime sAA. In the present study, we assayed daytime sAA in 20 suicidal PTSD patients who were randomized to prazosin versus placebo at bedtime-only, and found no effect in daytime sAA. These findings are consistent with studies showing an advantage for twice daily dosing of prazosin in PTSD.

AB - Overactivity of the noradrenergic (NE) system within the central nervous system (CNS) has been postulated as a key pathophysiology of posttraumatic stress disorder (PTSD). The activity of the enzyme salivary α-amylase (sAA) has been proposed as an indirect measure of CNS NE activity, and sAA is elevated in PTSD. As an antagonist of the α-1 NE receptor, prazosin would be expected to alter sAA values in PTSD patients. However, given its short half-life, it is not clear whether bedtime doses would have an effect on daytime sAA. In the present study, we assayed daytime sAA in 20 suicidal PTSD patients who were randomized to prazosin versus placebo at bedtime-only, and found no effect in daytime sAA. These findings are consistent with studies showing an advantage for twice daily dosing of prazosin in PTSD.

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Bedtime doses of prazosin do not affect daytime salivary amylase markers in PTSD

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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