Behavioral effects of d-amphetamine in humans: Influence of subclinical levels of inattention and hyperactivity

Rajkumar J. Sevak, William W. Stoops, Craig R. Rush

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objective: Several studies suggest a link between stimulant abuse and attention-deficit hyperactivity disorder (ADHD) symptoms (e.g., inattention and hyperactivity). To further assess the nature of this relationship, the present study examined the association between subclinical symptoms of inattention and hyperactivity and the behavioral effects of d-amphetamine. Methods: Participants were classified into a High- (n=8) or Low-Score (n=9) group based on their responses on a rating scale that assessed inattention and hyperactivity symptoms. Results: The participants did not differ across the High-Score and Low-Score groups in their ability to discriminate d-amphetamine. The participants in the High-Score group were significantly more sensitive to the positive participant-rated effects of d-amphetamine (e.g., Good Effects, Like Drug), but less sensitive to drug-induced increases in blood pressure and heart rate. Conclusion: The selective increase in positive subjective effects of d-amphetamine suggests that individuals with subclinical inattention and hyperactivity symptoms may have increased vulnerability to stimulant abuse.

Original languageEnglish
Pages (from-to)220-227
Number of pages8
JournalAmerican Journal of Drug and Alcohol Abuse
Issue number4
StatePublished - Jul 2010

Bibliographical note

Funding Information:
The National Institute on Drug Abuse Grants DA (RO1) 10325, 017711, and 13567 (C.R.R.) supported this research. The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.


  • Attention-deficit hyperactivity disorder
  • Behavior
  • D-amphetamine
  • Hyperactivity
  • Inattention
  • Substance abuse

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health


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