Behavioral effects of d-amphetamine in humans: Influence of subclinical levels of inattention and hyperactivity

Rajkumar J. Sevak; William W. Stoops; Craig R. Rush

doi:10.3109/00952990.2010.494213

Behavioral effects of d-amphetamine in humans: Influence of subclinical levels of inattention and hyperactivity

Rajkumar J. Sevak
, William W. Stoops
, Craig R. Rush

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objective: Several studies suggest a link between stimulant abuse and attention-deficit hyperactivity disorder (ADHD) symptoms (e.g., inattention and hyperactivity). To further assess the nature of this relationship, the present study examined the association between subclinical symptoms of inattention and hyperactivity and the behavioral effects of d-amphetamine. Methods: Participants were classified into a High- (n=8) or Low-Score (n=9) group based on their responses on a rating scale that assessed inattention and hyperactivity symptoms. Results: The participants did not differ across the High-Score and Low-Score groups in their ability to discriminate d-amphetamine. The participants in the High-Score group were significantly more sensitive to the positive participant-rated effects of d-amphetamine (e.g., Good Effects, Like Drug), but less sensitive to drug-induced increases in blood pressure and heart rate. Conclusion: The selective increase in positive subjective effects of d-amphetamine suggests that individuals with subclinical inattention and hyperactivity symptoms may have increased vulnerability to stimulant abuse.

Original language	English
Pages (from-to)	220-227
Number of pages	8
Journal	American Journal of Drug and Alcohol Abuse
Volume	36
Issue number	4
DOIs	https://doi.org/10.3109/00952990.2010.494213
State	Published - Jul 2010

Bibliographical note

Funding Information:
The National Institute on Drug Abuse Grants DA (RO1) 10325, 017711, and 13567 (C.R.R.) supported this research. The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.

Funding

The National Institute on Drug Abuse Grants DA (RO1) 10325, 017711, and 13567 (C.R.R.) supported this research. The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.

Funders	Funder number
National Institute on Drug Abuse	R01DA010325, 017711, 10325, 13567

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Attention-deficit hyperactivity disorder
Behavior
D-amphetamine
Hyperactivity
Inattention
Substance abuse

ASJC Scopus subject areas

Medicine (miscellaneous)
Clinical Psychology
Psychiatry and Mental health

Access to Document

10.3109/00952990.2010.494213

Cite this

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title = "Behavioral effects of d-amphetamine in humans: Influence of subclinical levels of inattention and hyperactivity",

abstract = "Objective: Several studies suggest a link between stimulant abuse and attention-deficit hyperactivity disorder (ADHD) symptoms (e.g., inattention and hyperactivity). To further assess the nature of this relationship, the present study examined the association between subclinical symptoms of inattention and hyperactivity and the behavioral effects of d-amphetamine. Methods: Participants were classified into a High- (n=8) or Low-Score (n=9) group based on their responses on a rating scale that assessed inattention and hyperactivity symptoms. Results: The participants did not differ across the High-Score and Low-Score groups in their ability to discriminate d-amphetamine. The participants in the High-Score group were significantly more sensitive to the positive participant-rated effects of d-amphetamine (e.g., Good Effects, Like Drug), but less sensitive to drug-induced increases in blood pressure and heart rate. Conclusion: The selective increase in positive subjective effects of d-amphetamine suggests that individuals with subclinical inattention and hyperactivity symptoms may have increased vulnerability to stimulant abuse.",

keywords = "Attention-deficit hyperactivity disorder, Behavior, D-amphetamine, Hyperactivity, Inattention, Substance abuse",

author = "Sevak, \{Rajkumar J.\} and Stoops, \{William W.\} and Rush, \{Craig R.\}",

note = "Funding Information: The National Institute on Drug Abuse Grants DA (RO1) 10325, 017711, and 13567 (C.R.R.) supported this research. The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.",

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T2 - Influence of subclinical levels of inattention and hyperactivity

AU - Sevak, Rajkumar J.

AU - Stoops, William W.

AU - Rush, Craig R.

N1 - Funding Information: The National Institute on Drug Abuse Grants DA (RO1) 10325, 017711, and 13567 (C.R.R.) supported this research. The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.

PY - 2010/7

Y1 - 2010/7

N2 - Objective: Several studies suggest a link between stimulant abuse and attention-deficit hyperactivity disorder (ADHD) symptoms (e.g., inattention and hyperactivity). To further assess the nature of this relationship, the present study examined the association between subclinical symptoms of inattention and hyperactivity and the behavioral effects of d-amphetamine. Methods: Participants were classified into a High- (n=8) or Low-Score (n=9) group based on their responses on a rating scale that assessed inattention and hyperactivity symptoms. Results: The participants did not differ across the High-Score and Low-Score groups in their ability to discriminate d-amphetamine. The participants in the High-Score group were significantly more sensitive to the positive participant-rated effects of d-amphetamine (e.g., Good Effects, Like Drug), but less sensitive to drug-induced increases in blood pressure and heart rate. Conclusion: The selective increase in positive subjective effects of d-amphetamine suggests that individuals with subclinical inattention and hyperactivity symptoms may have increased vulnerability to stimulant abuse.

AB - Objective: Several studies suggest a link between stimulant abuse and attention-deficit hyperactivity disorder (ADHD) symptoms (e.g., inattention and hyperactivity). To further assess the nature of this relationship, the present study examined the association between subclinical symptoms of inattention and hyperactivity and the behavioral effects of d-amphetamine. Methods: Participants were classified into a High- (n=8) or Low-Score (n=9) group based on their responses on a rating scale that assessed inattention and hyperactivity symptoms. Results: The participants did not differ across the High-Score and Low-Score groups in their ability to discriminate d-amphetamine. The participants in the High-Score group were significantly more sensitive to the positive participant-rated effects of d-amphetamine (e.g., Good Effects, Like Drug), but less sensitive to drug-induced increases in blood pressure and heart rate. Conclusion: The selective increase in positive subjective effects of d-amphetamine suggests that individuals with subclinical inattention and hyperactivity symptoms may have increased vulnerability to stimulant abuse.

KW - Attention-deficit hyperactivity disorder

KW - Behavior

KW - D-amphetamine

KW - Hyperactivity

KW - Inattention

KW - Substance abuse

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Behavioral effects of d-amphetamine in humans: Influence of subclinical levels of inattention and hyperactivity

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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