Beyond DNA repair: Additional functions of PARP-1 in cancer

Alice N. Weaver, Eddy S. Yang

Research output: Contribution to journalArticlepeer-review

181 Scopus citations


Poly(ADP-ribose) polymerases (PARPs) are DNA-dependent nuclear enzymes that transfer negatively charged ADP-ribose moieties from cellular nicotinamide-adenine-dinucleotide (NAD+) to a variety of protein substrates, altering protein-protein and protein-DNA interactions. The most studied of these enzymes is poly(ADP-ribose) polymerase-1 (PARP-1), which is an excellent therapeutic target in cancer due to its pivotal role in the DNA damage response. Clinical studies have shown susceptibility to PARP inhibitors in DNA repair defective cancers with only mild adverse side effects. Interestingly, additional studies are emerging which demonstrate a role for this therapy in DNA repair proficient tumors through a variety of mechanisms. In this review, we will discuss additional functions of PARP-1 - including regulation of inflammatory mediators, cellular energetics and death pathways, gene transcription, sex hormone- and ERK-mediated signaling, and mitosis - and the role these PARP-1-mediated processes play in oncogenesis, cancer progression, and the development of therapeutic resistance. As PARP-1 can act in both a pro- and anti-tumor manner depending on the context, it is important to consider the global effects of this protein in determining when, and how, to best use PARP inhibitors in anticancer therapy.

Original languageEnglish
Article number00290
JournalFrontiers in Oncology
Volume3 NOV
StatePublished - 2013


  • Angiogenesis
  • ERK signaling
  • Genetic transcription
  • Mitotic spindle
  • NF-κB
  • PARP inhibitors
  • PARP-1
  • Sex hormone signaling

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Beyond DNA repair: Additional functions of PARP-1 in cancer'. Together they form a unique fingerprint.

Cite this