Bilateral macrostomia in one of monozygotic twins

James K. Hartsfield, David Bixler

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


This report concerns a pair of monozygotic twins discordant for bilateral symmetrical macrostomia. Laterally placed, symmetrical notches in the vermilion borders of both upper and lower lips were apparent in the affected twin. Since the oral cavity walls develop by a differential growth and merging mechanism, this result suggests a mechanism of tissue breakdown as the cause of macrostomia. Furthermore, discordance in these monozygotic twins minimizes the importance of heredity in this malformation.

Original languageEnglish
Pages (from-to)648-651
Number of pages4
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Issue number6
StatePublished - Jun 1984

Bibliographical note

Funding Information:
Supported in part by the Oral Facial Genetics Training Grant DE 7043 from the National Institutes of Health. *At present Research Fellow in Orthodontics at Harvard School of Dental Medicine, Boston, Mass.

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • General Dentistry


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