Bilateral Radiation Optic Neuropathy Following Concurrent Chemotherapy and Radiation in Glioblastoma

Jigisha P. Thakkar, John T. Slevin, Charles D. Smith, Padmaja Sudhakar, William St. Clair, John L. Villano

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Radiation optic neuropathy (RON) is an iatrogenic complication that causes severe, irreversible vision loss within months to years following radiation to lesions close to the visual pathway. The authors describe a case of RON in glioblastoma after radio-sensitisation with temozolomide with sequential involvement of both optic nerves. This case provides a timeline for clinical and imaging findings with RON and specifically resolution of nerve enhancement. The authors also highlight the potential of an increase in incidence of RON in glioblastoma with advances in survival seen with greater use of second-line chemotherapy and even re-radiation.

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalNeuro-Ophthalmology
Volume41
Issue number5
DOIs
StatePublished - Sep 3 2017

Bibliographical note

Publisher Copyright:
© 2017 Taylor & Francis.

Keywords

  • Glioblastoma
  • radiation optic neuropathy
  • temozolomide

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

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