Abstract
Purpose of Review: To discuss recent advances indicating that bilirubin safeguards against cardiorenal and metabolic diseases. Recent Findings: Several investigations from human patient populations and experimental animal models have shown that bilirubin improves cardiorenal and metabolic dysfunction. The latest studies found an entirely new function of bilirubin suggesting that it acts as a hormone signaling molecule capable of activating nuclear receptors for burning fat, which may explain several of its protective actions. Summary: This review highlights the current findings (within the last 3 years) regarding cardiorenal and metabolic protective effects of bilirubin and the latest mechanism(s) that may be mediating these effects.
| Original language | English |
|---|---|
| Article number | 87 |
| Journal | Current Hypertension Reports |
| Volume | 21 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1 2019 |
Bibliographical note
Publisher Copyright:© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Funding
Terry D. Hinds, Jr. was supported by grants from the National Institutes of Health (NIH) K01HL125445 and R01DK121017 and funding from the University of Toledo Medical Research Society. David E. Stec was supported by grants R01HL088421 and P01HL-051971 from the National Heart, Lung and Blood Institute and grant P20GM-104357 from the National Institute of General Medical Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
| Funders | Funder number |
|---|---|
| University of Toledo Medical Research Society | P01HL-051971, R01HL088421 |
| National Institutes of Health (NIH) | R01DK121017 |
| National Heart, Lung, and Blood Institute (NHLBI) | K01HL125445 |
| National Institute of General Medical Sciences | P20GM104357 |
Keywords
- Biliverdin reductase
- Hypertension
- Kidney
- Metabolic syndrome
- PPARalpha
ASJC Scopus subject areas
- Internal Medicine
