Purpose of Review: To discuss recent advances indicating that bilirubin safeguards against cardiorenal and metabolic diseases. Recent Findings: Several investigations from human patient populations and experimental animal models have shown that bilirubin improves cardiorenal and metabolic dysfunction. The latest studies found an entirely new function of bilirubin suggesting that it acts as a hormone signaling molecule capable of activating nuclear receptors for burning fat, which may explain several of its protective actions. Summary: This review highlights the current findings (within the last 3 years) regarding cardiorenal and metabolic protective effects of bilirubin and the latest mechanism(s) that may be mediating these effects.

Original languageEnglish
Article number87
JournalCurrent Hypertension Reports
Issue number11
StatePublished - Nov 1 2019

Bibliographical note

Funding Information:
Terry D. Hinds, Jr. was supported by grants from the National Institutes of Health (NIH) K01HL125445 and R01DK121017 and funding from the University of Toledo Medical Research Society. David E. Stec was supported by grants R01HL088421 and P01HL-051971 from the National Heart, Lung and Blood Institute and grant P20GM-104357 from the National Institute of General Medical Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.


  • Biliverdin reductase
  • Hypertension
  • Kidney
  • Metabolic syndrome
  • PPARalpha

ASJC Scopus subject areas

  • Internal Medicine


Dive into the research topics of 'Bilirubin Safeguards Cardiorenal and Metabolic Diseases: a Protective Role in Health'. Together they form a unique fingerprint.

Cite this