TY - JOUR
T1 - Bimodal imaging using neodymium doped gadolinium fluoride nanocrystals with near-infrared to near-infrared downconversion luminescence and magnetic resonance properties
AU - Mimun, L. Christopher
AU - Ajithkumar, Gangadharan
AU - Pokhrel, Madhab
AU - Yust, Brian G.
AU - Elliott, Zak G.
AU - Pedraza, Francisco
AU - Dhanale, Ashish
AU - Tang, Liang
AU - Lin, Ai Ling
AU - Dravid, Vinayak P.
AU - Sardar, Dhiraj K.
PY - 2013/11/7
Y1 - 2013/11/7
N2 - Here we report the synthesis, characterization and application of a multifunctional surface functionalized GdF3:Nd3+ nanophosphor that exhibits efficient near infrared (NIR) fluorescence as well as magnetic properties, which can be utilized for bimodal imaging in medical applications. The nanoparticles are small with an average size of 5 nm and form stable colloids that last for several weeks without settling, enabling the use for several biomedical and photonic applications. Their excellent NIR properties, such as nearly 11% quantum yield of the 1064 nm emission, make them ideal contrast agents and biomarkers for in vitro and in vivo NIR optical bioimaging. The nanophosphors which were coated with poly(maleic anhydride-alt-1-octadicene) (PMAO) were implemented in cellular imaging, showing no significant cellular toxicity for concentrations up to 200 μg ml -1. Furthermore, the incorporation of Gd into the nanocrystalline structure renders them with exceptional magnetic properties, making them ideal for use as magnetic resonance imaging (MRI) contrast agents. The utility of these NIR emitting nanoparticles in infrared bioimaging and as contrast agents in magnetic resonance imaging was demonstrated by confocal imaging, magnetic resonance and tissue experiments.
AB - Here we report the synthesis, characterization and application of a multifunctional surface functionalized GdF3:Nd3+ nanophosphor that exhibits efficient near infrared (NIR) fluorescence as well as magnetic properties, which can be utilized for bimodal imaging in medical applications. The nanoparticles are small with an average size of 5 nm and form stable colloids that last for several weeks without settling, enabling the use for several biomedical and photonic applications. Their excellent NIR properties, such as nearly 11% quantum yield of the 1064 nm emission, make them ideal contrast agents and biomarkers for in vitro and in vivo NIR optical bioimaging. The nanophosphors which were coated with poly(maleic anhydride-alt-1-octadicene) (PMAO) were implemented in cellular imaging, showing no significant cellular toxicity for concentrations up to 200 μg ml -1. Furthermore, the incorporation of Gd into the nanocrystalline structure renders them with exceptional magnetic properties, making them ideal for use as magnetic resonance imaging (MRI) contrast agents. The utility of these NIR emitting nanoparticles in infrared bioimaging and as contrast agents in magnetic resonance imaging was demonstrated by confocal imaging, magnetic resonance and tissue experiments.
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U2 - 10.1039/c3tb20905a
DO - 10.1039/c3tb20905a
M3 - Article
AN - SCOPUS:84885120490
SN - 2050-7518
VL - 1
SP - 5702
EP - 5710
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 41
ER -