Binary blend of glyceryl monooleate and glyceryl monostearate for magnetically induced thermo-responsive local drug delivery system

Abebe E. Mengesha, Robert J. Wydra, J. Zach Hilt, Paul M. Bummer

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Purpose: To develop a novel monoglycerides-based thermal-sensitive drug delivery system, specifically for local intracavitary chemotherapy. Methods: Lipid matrices containing mixtures of glyceryl monooleate (GMO) and glyceryl monostearate (GMS) were evaluated for their potential application as magnetically induced thermo-responsive local drug delivery systems using a poorly water-soluble model drug, nifedipine (NF). Oleic acid-modified iron oxide (OA-Fe3O4) nanoparticles were embedded into the GMO-GMS matrix for remote activation of the drug release using an alternating magnetic field (AMF). Results: The crystallization behavior of binary blends of GMO and GMS as characterized by DSC did show temperature dependent phase transition. GMO-GMS (75:25 wt%) blend showed a melting (T m ) and crystallization (T c ) points at 42 C and 37 C, respectively indicating the potential of the matrix to act as an 'on-demand' drug release. The matrix released only 35% of the loaded drug slowly in 10 days at 37 C whereas 96% release was obtained at 42 C. A concentration of 0.5% OA-Fe3O 4 heated the matrix to 42.3 and 45.5 C within 5 min and 10 min of AMF exposure, respectively. Conclusions: The in vitro NF release profiles form the monoglycerides matrix containing 0.5% OA-Fe3O4 nanoparticles after AMF activation confirmed the thermo-responsive nature of the matrix that could provide pulsatile drug release 'on-demand'.

Original languageEnglish
Pages (from-to)3214-3224
Number of pages11
JournalPharmaceutical Research
Volume30
Issue number12
DOIs
StatePublished - Dec 2013

Keywords

  • local drug delivery
  • monoolein
  • monostearin
  • oleic acid-modified iron oxide nanoparticles
  • thermo-responsive monoglycerides

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)

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