Bioactive constituents from gum guggul (Commiphora wightii)

Nanqun Zhu; Mohamed M. Rafi; Robert S. DiPaola; Jingsong Xin; Chee Kok Chin; Vladimir Badmaev; Geetha Ghai; Robert T. Rosen; Chi Tang Ho

doi:10.1016/S0031-9422(00)00485-4

Bioactive constituents from gum guggul (Commiphora wightii)

Nanqun Zhu, Mohamed M. Rafi, Robert S. DiPaola, Jingsong Xin, Chee Kok Chin, Vladimir Badmaev, Geetha Ghai, Robert T. Rosen, Chi Tang Ho

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Bioactivity-directed fractionation and purification afforded cytotoxic components of Commiphora wightii. The exudates of C. wightii were extracted with EtOAc and the extract was subjected to repeated column chromatography. A fraction showing cytotoxic activity was characterized as a mixture of two ferulates with an unusual skeleton by spectral and chemical methods, including by NMR, GC-MS and chemical derivatization. This fraction also showed moderate scavenging effect against 2,2-diphenyl-l-picryl-hydrazyl (DPPH) radicals.

Original language	English
Pages (from-to)	723-727
Number of pages	5
Journal	Phytochemistry
Volume	56
Issue number	7
DOIs	https://doi.org/10.1016/S0031-9422(00)00485-4
State	Published - Apr 6 2001

Keywords

Berseracaea
Commiphora wightii
Cytotoxicity
DPPH
Ferulates
Polyhydroxyalkenyl esters

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/S0031-9422(00)00485-4

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title = "Bioactive constituents from gum guggul (Commiphora wightii)",

abstract = "Bioactivity-directed fractionation and purification afforded cytotoxic components of Commiphora wightii. The exudates of C. wightii were extracted with EtOAc and the extract was subjected to repeated column chromatography. A fraction showing cytotoxic activity was characterized as a mixture of two ferulates with an unusual skeleton by spectral and chemical methods, including by NMR, GC-MS and chemical derivatization. This fraction also showed moderate scavenging effect against 2,2-diphenyl-l-picryl-hydrazyl (DPPH) radicals.",

keywords = "Berseracaea, Commiphora wightii, Cytotoxicity, DPPH, Ferulates, Polyhydroxyalkenyl esters",

author = "Nanqun Zhu and Rafi, {Mohamed M.} and DiPaola, {Robert S.} and Jingsong Xin and Chin, {Chee Kok} and Vladimir Badmaev and Geetha Ghai and Rosen, {Robert T.} and Ho, {Chi Tang}",

year = "2001",

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doi = "10.1016/S0031-9422(00)00485-4",

language = "English",

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TY - JOUR

T1 - Bioactive constituents from gum guggul (Commiphora wightii)

AU - Zhu, Nanqun

AU - Rafi, Mohamed M.

AU - DiPaola, Robert S.

AU - Xin, Jingsong

AU - Chin, Chee Kok

AU - Badmaev, Vladimir

AU - Ghai, Geetha

AU - Rosen, Robert T.

AU - Ho, Chi Tang

PY - 2001/4/6

Y1 - 2001/4/6

N2 - Bioactivity-directed fractionation and purification afforded cytotoxic components of Commiphora wightii. The exudates of C. wightii were extracted with EtOAc and the extract was subjected to repeated column chromatography. A fraction showing cytotoxic activity was characterized as a mixture of two ferulates with an unusual skeleton by spectral and chemical methods, including by NMR, GC-MS and chemical derivatization. This fraction also showed moderate scavenging effect against 2,2-diphenyl-l-picryl-hydrazyl (DPPH) radicals.

AB - Bioactivity-directed fractionation and purification afforded cytotoxic components of Commiphora wightii. The exudates of C. wightii were extracted with EtOAc and the extract was subjected to repeated column chromatography. A fraction showing cytotoxic activity was characterized as a mixture of two ferulates with an unusual skeleton by spectral and chemical methods, including by NMR, GC-MS and chemical derivatization. This fraction also showed moderate scavenging effect against 2,2-diphenyl-l-picryl-hydrazyl (DPPH) radicals.

KW - Berseracaea

KW - Commiphora wightii

KW - Cytotoxicity

KW - DPPH

KW - Ferulates

KW - Polyhydroxyalkenyl esters

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U2 - 10.1016/S0031-9422(00)00485-4

DO - 10.1016/S0031-9422(00)00485-4

M3 - Article

C2 - 11314959

AN - SCOPUS:0035815334

SN - 0031-9422

VL - 56

SP - 723

EP - 727

JO - Phytochemistry

JF - Phytochemistry

IS - 7

ER -

Bioactive constituents from gum guggul (Commiphora wightii)

Abstract

Keywords

ASJC Scopus subject areas

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