Bioactive constituents from gum guggul (Commiphora wightii)

Nanqun Zhu, Mohamed M. Rafi, Robert S. DiPaola, Jingsong Xin, Chee Kok Chin, Vladimir Badmaev, Geetha Ghai, Robert T. Rosen, Chi Tang Ho

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Bioactivity-directed fractionation and purification afforded cytotoxic components of Commiphora wightii. The exudates of C. wightii were extracted with EtOAc and the extract was subjected to repeated column chromatography. A fraction showing cytotoxic activity was characterized as a mixture of two ferulates with an unusual skeleton by spectral and chemical methods, including by NMR, GC-MS and chemical derivatization. This fraction also showed moderate scavenging effect against 2,2-diphenyl-l-picryl-hydrazyl (DPPH) radicals.

Original languageEnglish
Pages (from-to)723-727
Number of pages5
JournalPhytochemistry
Volume56
Issue number7
DOIs
StatePublished - Apr 6 2001

Keywords

  • Berseracaea
  • Commiphora wightii
  • Cytotoxicity
  • DPPH
  • Ferulates
  • Polyhydroxyalkenyl esters

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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