Bioactive isocoumarins from a terrestrial Streptomyces sp. ANK302

Dhafer Saber Zinad; Khaled A. Shaaban; Muna Ali Abdalla; Md Tofazzal Islam; Anja Schüffler; Hartmut Laatsch

doi:10.1177/1934578x1100600111

Bioactive isocoumarins from a terrestrial Streptomyces sp. ANK302

Dhafer Saber Zinad, Khaled A. Shaaban, Muna Ali Abdalla, Md Tofazzal Islam, Anja Schüffler, Hartmut Laatsch

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Four isocoumarins have been isolated from the terrestrial Streptomyces sp. ANK302, namely 6,8-dimethoxy-3-methylisocoumarin (1), 6,8-dihydroxy-3- methylisocoumarin (2), 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (3), and 6,7,8-trimethoxy-3-methylisocoumarin (4). Compound 1 is a new naturally-occurring isocoumarin, and 2 was isolated as a new bacterial product. The structures 1-4 were deduced from high resolution mass, 1D and 2D NMR spectra and by comparison with related compounds from the literature. Compound 2 showed a strong zoosporicidal activity at a concentration of 5 μg/mL against a phytopathogenic oomycete, Plasmopara viticola, and 1 was active against Candida albicans.

Original language	English
Pages (from-to)	45-48
Number of pages	4
Journal	Natural Product Communications
Volume	6
Issue number	1
DOIs	https://doi.org/10.1177/1934578x1100600111
State	Published - Jan 2011

Keywords

Isocoumarins
Oomycetes
Terrestrial Streptomyces
Zoosporicide

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Plant Science
Complementary and alternative medicine

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10.1177/1934578x1100600111

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title = "Bioactive isocoumarins from a terrestrial Streptomyces sp. ANK302",

abstract = "Four isocoumarins have been isolated from the terrestrial Streptomyces sp. ANK302, namely 6,8-dimethoxy-3-methylisocoumarin (1), 6,8-dihydroxy-3- methylisocoumarin (2), 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (3), and 6,7,8-trimethoxy-3-methylisocoumarin (4). Compound 1 is a new naturally-occurring isocoumarin, and 2 was isolated as a new bacterial product. The structures 1-4 were deduced from high resolution mass, 1D and 2D NMR spectra and by comparison with related compounds from the literature. Compound 2 showed a strong zoosporicidal activity at a concentration of 5 μg/mL against a phytopathogenic oomycete, Plasmopara viticola, and 1 was active against Candida albicans.",

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language = "English",

volume = "6",

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AU - Zinad, Dhafer Saber

AU - Shaaban, Khaled A.

AU - Ali Abdalla, Muna

AU - Islam, Md Tofazzal

AU - Schüffler, Anja

AU - Laatsch, Hartmut

PY - 2011/1

Y1 - 2011/1

N2 - Four isocoumarins have been isolated from the terrestrial Streptomyces sp. ANK302, namely 6,8-dimethoxy-3-methylisocoumarin (1), 6,8-dihydroxy-3- methylisocoumarin (2), 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (3), and 6,7,8-trimethoxy-3-methylisocoumarin (4). Compound 1 is a new naturally-occurring isocoumarin, and 2 was isolated as a new bacterial product. The structures 1-4 were deduced from high resolution mass, 1D and 2D NMR spectra and by comparison with related compounds from the literature. Compound 2 showed a strong zoosporicidal activity at a concentration of 5 μg/mL against a phytopathogenic oomycete, Plasmopara viticola, and 1 was active against Candida albicans.

AB - Four isocoumarins have been isolated from the terrestrial Streptomyces sp. ANK302, namely 6,8-dimethoxy-3-methylisocoumarin (1), 6,8-dihydroxy-3- methylisocoumarin (2), 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (3), and 6,7,8-trimethoxy-3-methylisocoumarin (4). Compound 1 is a new naturally-occurring isocoumarin, and 2 was isolated as a new bacterial product. The structures 1-4 were deduced from high resolution mass, 1D and 2D NMR spectra and by comparison with related compounds from the literature. Compound 2 showed a strong zoosporicidal activity at a concentration of 5 μg/mL against a phytopathogenic oomycete, Plasmopara viticola, and 1 was active against Candida albicans.

KW - Isocoumarins

KW - Oomycetes

KW - Terrestrial Streptomyces

KW - Zoosporicide

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JO - Natural Product Communications

JF - Natural Product Communications

IS - 1

ER -

Bioactive isocoumarins from a terrestrial Streptomyces sp. ANK302

Abstract

Keywords

ASJC Scopus subject areas

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