Bioactive isocoumarins from a terrestrial Streptomyces sp. ANK302

Dhafer Saber Zinad, Khaled A. Shaaban, Muna Ali Abdalla, Md Tofazzal Islam, Anja Schüffler, Hartmut Laatsch

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Four isocoumarins have been isolated from the terrestrial Streptomyces sp. ANK302, namely 6,8-dimethoxy-3-methylisocoumarin (1), 6,8-dihydroxy-3- methylisocoumarin (2), 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (3), and 6,7,8-trimethoxy-3-methylisocoumarin (4). Compound 1 is a new naturally-occurring isocoumarin, and 2 was isolated as a new bacterial product. The structures 1-4 were deduced from high resolution mass, 1D and 2D NMR spectra and by comparison with related compounds from the literature. Compound 2 showed a strong zoosporicidal activity at a concentration of 5 μg/mL against a phytopathogenic oomycete, Plasmopara viticola, and 1 was active against Candida albicans.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalNatural Product Communications
Issue number1
StatePublished - Jan 2011


  • Isocoumarins
  • Oomycetes
  • Terrestrial Streptomyces
  • Zoosporicide

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine


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