TY - JOUR
T1 - Bioactive lipids and circulating progenitor cells in patients with cardiovascular disease
AU - Hayek, Salim S.
AU - Klyachkin, Yuri
AU - Asfour, Ahmed
AU - Ghasemzadeh, Nima
AU - Awad, Mosaab
AU - Hesaroieh, Iraj
AU - Ahmed, Hina
AU - Gray, Brandon
AU - Kim, Jinhee
AU - Waller, Edmund K.
AU - Quyyumi, Arshed A.
AU - Abdel-Latif, Ahmed K.
N1 - Publisher Copyright:
© 2017 The Authors.
PY - 2017/3
Y1 - 2017/3
N2 - Bone marrow-derived progenitor cells are mobilized into the peripheral blood after acute myocardial injury and in chronic ischemic heart disease. However, the mechanisms responsible for this mobilization are poorly understood. We examined the relationship between plasma levels of bioactive lipids and number of circulating progenitor cells (CPCs) in patients (N = 437) undergoing elective or emergent cardiac catheterization. Plasma levels of sphingosine-1 phosphate (S1P) and ceramide-1 phosphate (C1P) were quantified using mass spectrometry. CPCs were assessed using flow cytometry. S1P levels correlated with the numbers of CD341, CD341/CD1331, and CD341/CXCR41CPCs even after adjustment for potential confounding factors. However, no significant correlation was observed between C1P levels and CPC count. Plasma levels of S1P correlated with the number of CPCs in patients with coronary artery disease, suggesting an important mechanistic role for S1P in stem cell mobilization. The therapeutic effects of adjunctive S1P therapy to mobilize endogenous stem cells need to be investigated.
AB - Bone marrow-derived progenitor cells are mobilized into the peripheral blood after acute myocardial injury and in chronic ischemic heart disease. However, the mechanisms responsible for this mobilization are poorly understood. We examined the relationship between plasma levels of bioactive lipids and number of circulating progenitor cells (CPCs) in patients (N = 437) undergoing elective or emergent cardiac catheterization. Plasma levels of sphingosine-1 phosphate (S1P) and ceramide-1 phosphate (C1P) were quantified using mass spectrometry. CPCs were assessed using flow cytometry. S1P levels correlated with the numbers of CD341, CD341/CD1331, and CD341/CXCR41CPCs even after adjustment for potential confounding factors. However, no significant correlation was observed between C1P levels and CPC count. Plasma levels of S1P correlated with the number of CPCs in patients with coronary artery disease, suggesting an important mechanistic role for S1P in stem cell mobilization. The therapeutic effects of adjunctive S1P therapy to mobilize endogenous stem cells need to be investigated.
KW - Ceramide-1 phosphate
KW - Circulating progenitor cell
KW - Coronary artery disease
KW - Mobilization
KW - Sphingosine-1 phosphate
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UR - http://www.scopus.com/inward/citedby.url?scp=85017539802&partnerID=8YFLogxK
U2 - 10.5966/sctm.2016-0059
DO - 10.5966/sctm.2016-0059
M3 - Article
C2 - 28297574
AN - SCOPUS:85017539802
SN - 2157-6564
VL - 6
SP - 731
EP - 735
JO - Stem cells translational medicine
JF - Stem cells translational medicine
IS - 3
ER -
