Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae

Günther Daum, Norman D. Lees, Martin Bard, Robert Dickson

Research output: Contribution to journalReview articlepeer-review

544 Scopus citations

Abstract

The yeast Saccharomyces cerevisiae is a powerful experimental system to study biochemical, cell biological and molecular biological aspects of lipid synthesis. Most but not all genes encoding enzymes involved in fatty acid, phospholipid, sterol or sphingolipid biosynthesis of this unicellular eukaryote have been cloned, and many gene products have been functionally characterized. Less information is available about genes and gene products governing the transport of lipids between organelles and within membranes, turnover and degradation of complex lipids, regulation of lipid biosynthesis, and linkage of lipid metabolism to other cellular processes. Here we summarize current knowledge about lipid biosynthetic pathways in S. cerevisiae and describe the characteristic features of the gene products involved. We focus on recent discoveries in these fields and address questions on the regulation of lipid synthesis, subcellular localization of lipid biosynthetic steps, cross-talk between organelles during lipid synthesis and subcellular distribution of lipids. Finally we discuss distinct functions of certain key lipids and their possible roles in cellular processes.

Original languageEnglish
Pages (from-to)1471-1510
Number of pages40
JournalYeast
Volume14
Issue number16
DOIs
StatePublished - Dec 1998

Keywords

  • Fatty acids
  • Lipids
  • Phospholipids
  • S. cerevisiae
  • Sphingolipids
  • Sterols
  • Yeast

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Genetics

Fingerprint

Dive into the research topics of 'Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae'. Together they form a unique fingerprint.

Cite this