Bioerodible system for sequential release of multiple drugs

Sharath C. Sundararaj, Mark V. Thomas, Thomas D. Dziubla, David A. Puleo

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Because many complex physiological processes are controlled by multiple biomolecules, comprehensive treatment of certain disease conditions may be more effectively achieved by administration of more than one type of drug. Thus, the objective of the present research was to develop a multilayered, polymer-based system for sequential delivery of multiple drugs. The polymers used were cellulose acetate phthalate (CAP) complexed with Pluronic F-127 (P). After evaluating morphology of the resulting CAPP system, in vitro release of small molecule drugs and a model protein was studied from both single and multilayered devices. Drug release from single-layered CAPP films followed zero-order kinetics related to surface erosion of the association polymer. Release studies from multilayered CAPP devices showed the possibility of achieving intermittent release of one type of drug as well as sequential release of more than one type of drug. Mathematical modeling accurately predicted the release profiles for both single layer and multilayered devices. The present CAPP association polymer-based multilayer devices can be used for localized, sequential delivery of multiple drugs for the possible treatment of complex disease conditions, and perhaps for tissue engineering applications, that require delivery of more than one type of biomolecule.

Original languageEnglish
Pages (from-to)115-125
Number of pages11
JournalActa Biomaterialia
Volume10
Issue number1
DOIs
StatePublished - Jan 2014

Bibliographical note

Funding Information:
This research was supported by NIH ( DE019645 and AR060964 ) and Kentucky NASA EPSCo R ( NNX08BA13A ). We dedicate this work in memory of Dr. Mark V. Thomas, who passed away as the studies were being conducted.

Keywords

  • Cellulose acetate phthalate
  • Multiple drug delivery
  • Pluronic F-127
  • Sequential drug release
  • Zero-order release

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

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