TY - JOUR
T1 - Biological implications of long-term anthelmintic treatment
T2 - what else besides resistance are we selecting for?
AU - Nielsen, Martin K.
AU - Kaplan, Ray M.
AU - Abbas, Ghazanfar
AU - Jabbar, Abdul
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/11
Y1 - 2023/11
N2 - Long-term intensive use of anthelmintics for parasite control of livestock, companion animals, and humans has resulted in widespread anthelmintic resistance, a problem of great socioeconomic significance. But anthelmintic therapy may also select for other biological traits, which could have implications for anthelmintic performance. Here, we highlight recent examples of changing parasite dynamics following anthelmintic administration, which do not fit the definition of anthelmintic resistance. We also consider other possible examples in which anthelmintic resistance has clearly established, but where coselection for other biological traits may have also occurred. We offer suggestions for collecting more information and gaining a better understanding of these phenomena. Finally, we propose research questions that require further investigation and make suggestions to help address these knowledge gaps.
AB - Long-term intensive use of anthelmintics for parasite control of livestock, companion animals, and humans has resulted in widespread anthelmintic resistance, a problem of great socioeconomic significance. But anthelmintic therapy may also select for other biological traits, which could have implications for anthelmintic performance. Here, we highlight recent examples of changing parasite dynamics following anthelmintic administration, which do not fit the definition of anthelmintic resistance. We also consider other possible examples in which anthelmintic resistance has clearly established, but where coselection for other biological traits may have also occurred. We offer suggestions for collecting more information and gaining a better understanding of these phenomena. Finally, we propose research questions that require further investigation and make suggestions to help address these knowledge gaps.
KW - Onchocerca
KW - cyathostomin
KW - egg reappearance
KW - microfilarial repopulation
KW - selection
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U2 - 10.1016/j.pt.2023.08.002
DO - 10.1016/j.pt.2023.08.002
M3 - Review article
C2 - 37633759
AN - SCOPUS:85171428522
SN - 1471-4922
VL - 39
SP - 945
EP - 953
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 11
ER -