Biological implications of long-term anthelmintic treatment: what else besides resistance are we selecting for?

Martin K. Nielsen, Ray M. Kaplan, Ghazanfar Abbas, Abdul Jabbar

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Long-term intensive use of anthelmintics for parasite control of livestock, companion animals, and humans has resulted in widespread anthelmintic resistance, a problem of great socioeconomic significance. But anthelmintic therapy may also select for other biological traits, which could have implications for anthelmintic performance. Here, we highlight recent examples of changing parasite dynamics following anthelmintic administration, which do not fit the definition of anthelmintic resistance. We also consider other possible examples in which anthelmintic resistance has clearly established, but where coselection for other biological traits may have also occurred. We offer suggestions for collecting more information and gaining a better understanding of these phenomena. Finally, we propose research questions that require further investigation and make suggestions to help address these knowledge gaps.

Original languageEnglish
Pages (from-to)945-953
Number of pages9
JournalTrends in Parasitology
Volume39
Issue number11
DOIs
StatePublished - Nov 2023

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Ltd

Keywords

  • Onchocerca
  • cyathostomin
  • egg reappearance
  • microfilarial repopulation
  • selection

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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