Abstract
Objective: To investigate biological markers of peri-implantitis (PIP) in crevicular fluid before and after surgical and antimicrobial therapy. Material and Methods: Forty-eight participants (24 healthy implants and 24 PIP) were clinically evaluated, and peri-implant crevicular fluid (PICF) samples were collected at baseline for both groups, and at 3-months after surgical and antimicrobial treatment (ie, n = 21 PIP completers). Samples were analyzed for interleukin-1β (IL-1β), matrix metalloproteinase-8 (MMP-8), and macrophage inflammatory protein-1α (MIP-1α) using immunoassay and the results compared between groups. Results: Peri-implantitis sites at baseline demonstrated significantly higher mean periodontal probing depths, percentage bleeding on probing (P ≤ 0.001), and mean IL-1β concentration in PICF compared to healthy implant sites (17.9 vs 1.7 pg/μL; P = 0.02). Three months after treatment, periodontal probing depths, bleeding on probing, suppuration (P < 0.05), and the mean concentration of MMP-8 decreased significantly compared with baseline (12.1 vs 6.7 ng/μL, P = 0.04). MIP-1α concentrations showed no differences between the groups. Conclusion: Elevated concentrations of IL-1β in PICF were consistent with PIP. A decrease in MMP-8 concentration in PICF at three months after treatment is consistent with a healing biological response.
Original language | English |
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Pages (from-to) | 720-728 |
Number of pages | 9 |
Journal | Journal of Periodontal Research |
Volume | 54 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1 2019 |
Bibliographical note
Funding Information:The authors thank Horton Li (University of Kentucky) for assistance with patient screening and sample collection, and Jason Stevens (University of Kentucky) for help with laboratory analysis.
Publisher Copyright:
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Keywords
- biomarkers
- crevicular fluid
- dental implants
- peri-implantitis
ASJC Scopus subject areas
- Periodontics