Biology of cardiac arrhythmias: Ion channel protein trafficking

Brian P. Delisle, Blake D. Anson, Sridharan Rajamani, Craig T. January

Research output: Contribution to journalReview articlepeer-review

181 Citations (SciVal)

Abstract

The mechanisms underlying normal and abnormal cardiac rhythms are complex and incompletely understood. Through the study of uncommon inheritable arrhythmia syndromes, including the long QT and Brugada syndromes, new insights are emerging. At the cellular and tissue levels, we now recognize that ion channel current is the sum of biophysical (gating, permeation), biochemical (phosphorylation, etc), and biogenic (biosynthesis, processing, trafficking, and degradation) properties. This review focuses on how heart cells process ion channel proteins and how this protein trafficking may be altered in some cardiac arrhythmia diseases. In this review, we honor Dr Harry A. Fozzard, a modern pioneer in cardiac arrhythmias, cell biology, and molecular electrophysiology. As a scientist and physician, his writings and mentorship have served to foster a generation of investigators who continue to bring this complex field toward greater scientific understanding and impact on humankind.

Original languageEnglish
Pages (from-to)1418-1428
Number of pages11
JournalCirculation Research
Volume94
Issue number11
DOIs
StatePublished - Jun 11 2004

Keywords

  • Arrhythmia
  • Cell biology
  • Ion channels
  • Protein trafficking

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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