Biology of secretory phospholipase A₂

The secretory phospholipase A₂ (sPLA₂) family provides a seemingly endless array of potential biological functions that is only beginning to be appreciated. In humans, this family comprises 9 different members that vary in their tissue distribution, hydrolytic activity, and phospholipid substrate specificity. Through their lipase activity, these enzymes trigger various cell-signaling events to regulate cellular functions, directly kill bacteria, or modulate inflammatory responses. In addition, some sPLA ₂'s are high affinity ligands for cellular receptors. This review merely scratches the surface of some of the actions of sPLA₂s in innate immunity, inflammation, and atherosclerosis. The goal is to provide an overview of recent findings involving sPLA₂s and to point to potential pathophysiologic mechanisms that may become targets for therapy.