Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update

Melissa A. Bradley-Whitman, Mark A. Lovell

Research output: Contribution to journalReview articlepeer-review

121 Scopus citations

Abstract

Increasing evidence suggests that free radical-mediated oxidation of biological substrates is a key feature of Alzheimer’s disease (AD) pathogenesis. While it has long been established that biomarkers of lipid peroxidation (LPO) are elevated in AD brain as well as ventricular CSF postmortem, more recent studies have demonstrated increased LPO biomarkers in postmortem brain from subjects with mild cognitive impairment, the earliest clinically detectable phase of dementia and preclinical AD, the earliest detectable pathological phase. Furthermore, multiple LPO biomarkers are elevated in readily accessible biological fluids throughout disease progression. Collectively, these studies demonstrate that LPO is an early feature during disease progression and may be considered a key pathway for targeted therapeutics as well as an enhancer of diagnostic accuracy for early detection of subjects during the prodromal phase.

Original languageEnglish
Pages (from-to)1035-1044
Number of pages10
JournalArchives of Toxicology
Volume89
Issue number7
DOIs
StatePublished - Jul 15 2015

Bibliographical note

Publisher Copyright:
© 2015, Springer-Verlag Berlin Heidelberg.

Keywords

  • Alzheimer’s disease
  • Lipid peroxidation
  • Mild cognitive impairment
  • Oxidative stress
  • Preclinical Alzheimer’s disease

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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