Abstract
This chapter reviews the involvement of oxidative stress in neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). Studies conducted thus far suggest that oxidation and nitration of proteins are involved in the progression and pathology of AD, PD, and ALS. Based on research, there is much evidence for the elevation of the peripheral lipoperoxidation markers in several neurodegenerative diseases. The chapter also discusses biomarkers of carbohydrate oxidation and nucleic acid oxidation, in detail. However, so far, there are no unique set of markers that can help to differentiate neurodegenerative diseases or use of the oxidative stress markers as specific biomarkers of the diseases. Studies are ongoing in the authors' laboratory to identify disease-specific biomarkers which can be used in both diagnosis or to monitor the protective efficacy of therapeutic agents.
| Original language | English |
|---|---|
| Title of host publication | Molecular Basis of Oxidative Stress |
| Subtitle of host publication | Chemistry, Mechanisms, and Disease Pathogenesis |
| Pages | 359-376 |
| Number of pages | 18 |
| ISBN (Electronic) | 9780470572184 |
| DOIs | |
| State | Published - Jan 1 2013 |
Bibliographical note
Publisher Copyright:© 2013 by John Wiley and Sons, Inc. All rights reserved.
Keywords
- Biomarkers
- Carbohydrate oxidation
- Lipid peroxidation
- Neurodegenerative diseases
- Nucleic acid oxidation
- Oxidative stress
- Protein nitration
- Protein oxidation
ASJC Scopus subject areas
- General Chemistry
- General Chemical Engineering
- General Pharmacology, Toxicology and Pharmaceutics
- General Biochemistry, Genetics and Molecular Biology