Biomarkers to assess the targeting of DNA repair pathways to augment tumor response to therapy

S. Nowsheen; A. C. Whitley; E. S. Yang

doi:10.2174/156652412800792615

Biomarkers to assess the targeting of DNA repair pathways to augment tumor response to therapy

S. Nowsheen, A. C. Whitley, E. S. Yang

Radiation Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Hyper-activation of DNA repair pathways can enable tumor cells to survive DNA damage. Therefore, targeting specific DNA repair pathways might prove efficacious for cancer therapy. The advent of personalized therapy necessitates novel biomarkers to assess tumor response to therapy. Biological indicators are vital in the field of cancer research and treatment. The focus of this review is on the DNA repair machinery as an emerging target for enhancement of therapy. Additionally, DNA damage and repair biomarkers for prognosis in different types of cancer will be discussed. The application of biomarkers to assess tumor response to therapy based on targeting DNA repair pathways can potentially improve patient quality of life and aid in treatment design.

Original language	English
Pages (from-to)	788-803
Number of pages	16
Journal	Current Molecular Medicine
Volume	12
Issue number	6
DOIs	https://doi.org/10.2174/156652412800792615
State	Published - Jul 2012

Keywords

Biomarkers
Cancer therapy
DNA damage
DNA repair
PARP inhibitor
Personalized medicine

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2174/156652412800792615

Cite this

@article{aa60e5b334ca4192b5e160235d82f809,

title = "Biomarkers to assess the targeting of DNA repair pathways to augment tumor response to therapy",

abstract = "Hyper-activation of DNA repair pathways can enable tumor cells to survive DNA damage. Therefore, targeting specific DNA repair pathways might prove efficacious for cancer therapy. The advent of personalized therapy necessitates novel biomarkers to assess tumor response to therapy. Biological indicators are vital in the field of cancer research and treatment. The focus of this review is on the DNA repair machinery as an emerging target for enhancement of therapy. Additionally, DNA damage and repair biomarkers for prognosis in different types of cancer will be discussed. The application of biomarkers to assess tumor response to therapy based on targeting DNA repair pathways can potentially improve patient quality of life and aid in treatment design.",

keywords = "Biomarkers, Cancer therapy, DNA damage, DNA repair, PARP inhibitor, Personalized medicine",

author = "S. Nowsheen and Whitley, {A. C.} and Yang, {E. S.}",

year = "2012",

month = jul,

doi = "10.2174/156652412800792615",

language = "English",

volume = "12",

pages = "788--803",

journal = "Current Molecular Medicine",

issn = "1566-5240",

publisher = "Bentham Science Publishers B.V.",

number = "6",

}

TY - JOUR

T1 - Biomarkers to assess the targeting of DNA repair pathways to augment tumor response to therapy

AU - Nowsheen, S.

AU - Whitley, A. C.

AU - Yang, E. S.

PY - 2012/7

Y1 - 2012/7

N2 - Hyper-activation of DNA repair pathways can enable tumor cells to survive DNA damage. Therefore, targeting specific DNA repair pathways might prove efficacious for cancer therapy. The advent of personalized therapy necessitates novel biomarkers to assess tumor response to therapy. Biological indicators are vital in the field of cancer research and treatment. The focus of this review is on the DNA repair machinery as an emerging target for enhancement of therapy. Additionally, DNA damage and repair biomarkers for prognosis in different types of cancer will be discussed. The application of biomarkers to assess tumor response to therapy based on targeting DNA repair pathways can potentially improve patient quality of life and aid in treatment design.

AB - Hyper-activation of DNA repair pathways can enable tumor cells to survive DNA damage. Therefore, targeting specific DNA repair pathways might prove efficacious for cancer therapy. The advent of personalized therapy necessitates novel biomarkers to assess tumor response to therapy. Biological indicators are vital in the field of cancer research and treatment. The focus of this review is on the DNA repair machinery as an emerging target for enhancement of therapy. Additionally, DNA damage and repair biomarkers for prognosis in different types of cancer will be discussed. The application of biomarkers to assess tumor response to therapy based on targeting DNA repair pathways can potentially improve patient quality of life and aid in treatment design.

KW - Biomarkers

KW - Cancer therapy

KW - DNA damage

KW - DNA repair

KW - PARP inhibitor

KW - Personalized medicine

UR - http://www.scopus.com/inward/record.url?scp=84862537645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862537645&partnerID=8YFLogxK

U2 - 10.2174/156652412800792615

DO - 10.2174/156652412800792615

M3 - Article

C2 - 22292444

AN - SCOPUS:84862537645

SN - 1566-5240

VL - 12

SP - 788

EP - 803

JO - Current Molecular Medicine

JF - Current Molecular Medicine

IS - 6

ER -

Biomarkers to assess the targeting of DNA repair pathways to augment tumor response to therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this