Biomaterial strategies for creating in vitro astrocyte cultures resembling in vivo astrocyte morphologies and phenotypes

Manoj K. Gottipati; Jonathan M. Zuidema; Ryan J. Gilbert

doi:10.1016/j.cobme.2020.06.004

Biomaterial strategies for creating in vitro astrocyte cultures resembling in vivo astrocyte morphologies and phenotypes

Manoj K. Gottipati, Jonathan M. Zuidema, Ryan J. Gilbert

Mechanical and Aerospace Engineering

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Astrocytes are dynamic cells residing in the central nervous system exhibiting many diverse functions. Astrocytes quickly change and present unique phenotypes in response to injury or disease. Here, we briefly summarize recent information regarding astrocyte morphology and function and provide brief insight into their phenotypic changes after injury or disease. We also present the use of in vitro astrocyte cultures and present recent advances in biomaterial development that enable better recapitulation of their in vivo behavior and morphology.

Original language	English
Pages (from-to)	67-74
Number of pages	8
Journal	Current Opinion in Biomedical Engineering
Volume	14
DOIs	https://doi.org/10.1016/j.cobme.2020.06.004
State	Published - Jun 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Funding

The authors would like to acknowledge the following funding sources: Craig H. Neilsen Foundation Postdoctoral Fellowship ( 468116 ) and Paralyzed Veterans of America Research Foundation Postdoctoral Fellowship ( 3171 ) to MKG, NIH R01 ( NS092754 ) and New York State Spinal Cord Injury Review Board Institutional Support Grant ( C32245GG ) to RJG. All the figures were created with BioRender.com.

Funders	Funder number
National Institutes of Health (NIH)	C32245GG, NS092754
National Institutes of Health (NIH)
Craig H. Neilsen Foundation	3171, 468116
Craig H. Neilsen Foundation

Keywords

3D cultures
Astrocytes
Biomaterials
Reactive astrogliosis

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomaterials
Biomedical Engineering

Access to Document

10.1016/j.cobme.2020.06.004

Cite this

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abstract = "Astrocytes are dynamic cells residing in the central nervous system exhibiting many diverse functions. Astrocytes quickly change and present unique phenotypes in response to injury or disease. Here, we briefly summarize recent information regarding astrocyte morphology and function and provide brief insight into their phenotypic changes after injury or disease. We also present the use of in vitro astrocyte cultures and present recent advances in biomaterial development that enable better recapitulation of their in vivo behavior and morphology.",

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AU - Zuidema, Jonathan M.

AU - Gilbert, Ryan J.

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N2 - Astrocytes are dynamic cells residing in the central nervous system exhibiting many diverse functions. Astrocytes quickly change and present unique phenotypes in response to injury or disease. Here, we briefly summarize recent information regarding astrocyte morphology and function and provide brief insight into their phenotypic changes after injury or disease. We also present the use of in vitro astrocyte cultures and present recent advances in biomaterial development that enable better recapitulation of their in vivo behavior and morphology.

AB - Astrocytes are dynamic cells residing in the central nervous system exhibiting many diverse functions. Astrocytes quickly change and present unique phenotypes in response to injury or disease. Here, we briefly summarize recent information regarding astrocyte morphology and function and provide brief insight into their phenotypic changes after injury or disease. We also present the use of in vitro astrocyte cultures and present recent advances in biomaterial development that enable better recapitulation of their in vivo behavior and morphology.

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KW - Astrocytes

KW - Biomaterials

KW - Reactive astrogliosis

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JO - Current Opinion in Biomedical Engineering

JF - Current Opinion in Biomedical Engineering

ER -

Biomaterial strategies for creating in vitro astrocyte cultures resembling in vivo astrocyte morphologies and phenotypes

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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