Biomaterial strategies for creating in vitro astrocyte cultures resembling in vivo astrocyte morphologies and phenotypes

Manoj K. Gottipati; Jonathan M. Zuidema; Ryan J. Gilbert

doi:10.1016/j.cobme.2020.06.004

Biomaterial strategies for creating in vitro astrocyte cultures resembling in vivo astrocyte morphologies and phenotypes

Manoj K. Gottipati, Jonathan M. Zuidema, Ryan J. Gilbert

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Astrocytes are dynamic cells residing in the central nervous system exhibiting many diverse functions. Astrocytes quickly change and present unique phenotypes in response to injury or disease. Here, we briefly summarize recent information regarding astrocyte morphology and function and provide brief insight into their phenotypic changes after injury or disease. We also present the use of in vitro astrocyte cultures and present recent advances in biomaterial development that enable better recapitulation of their in vivo behavior and morphology.

Original language	English
Pages (from-to)	67-74
Number of pages	8
Journal	Current Opinion in Biomedical Engineering
Volume	14
DOIs	https://doi.org/10.1016/j.cobme.2020.06.004
State	Published - Jun 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

3D cultures
Astrocytes
Biomaterials
Reactive astrogliosis

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomaterials
Biomedical Engineering

Access to Document

10.1016/j.cobme.2020.06.004

Cite this

@article{da95f2210c514fb3889675410fcc4054,

title = "Biomaterial strategies for creating in vitro astrocyte cultures resembling in vivo astrocyte morphologies and phenotypes",

abstract = "Astrocytes are dynamic cells residing in the central nervous system exhibiting many diverse functions. Astrocytes quickly change and present unique phenotypes in response to injury or disease. Here, we briefly summarize recent information regarding astrocyte morphology and function and provide brief insight into their phenotypic changes after injury or disease. We also present the use of in vitro astrocyte cultures and present recent advances in biomaterial development that enable better recapitulation of their in vivo behavior and morphology.",

keywords = "3D cultures, Astrocytes, Biomaterials, Reactive astrogliosis",

author = "Gottipati, {Manoj K.} and Zuidema, {Jonathan M.} and Gilbert, {Ryan J.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = jun,

doi = "10.1016/j.cobme.2020.06.004",

language = "English",

volume = "14",

pages = "67--74",

journal = "Current Opinion in Biomedical Engineering",

issn = "2468-4511",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Biomaterial strategies for creating in vitro astrocyte cultures resembling in vivo astrocyte morphologies and phenotypes

AU - Gottipati, Manoj K.

AU - Zuidema, Jonathan M.

AU - Gilbert, Ryan J.

PY - 2020/6

Y1 - 2020/6

N2 - Astrocytes are dynamic cells residing in the central nervous system exhibiting many diverse functions. Astrocytes quickly change and present unique phenotypes in response to injury or disease. Here, we briefly summarize recent information regarding astrocyte morphology and function and provide brief insight into their phenotypic changes after injury or disease. We also present the use of in vitro astrocyte cultures and present recent advances in biomaterial development that enable better recapitulation of their in vivo behavior and morphology.

AB - Astrocytes are dynamic cells residing in the central nervous system exhibiting many diverse functions. Astrocytes quickly change and present unique phenotypes in response to injury or disease. Here, we briefly summarize recent information regarding astrocyte morphology and function and provide brief insight into their phenotypic changes after injury or disease. We also present the use of in vitro astrocyte cultures and present recent advances in biomaterial development that enable better recapitulation of their in vivo behavior and morphology.

KW - 3D cultures

KW - Astrocytes

KW - Biomaterials

KW - Reactive astrogliosis

UR - http://www.scopus.com/inward/record.url?scp=85088400910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85088400910&partnerID=8YFLogxK

U2 - 10.1016/j.cobme.2020.06.004

DO - 10.1016/j.cobme.2020.06.004

M3 - Review article

AN - SCOPUS:85088400910

SN - 2468-4511

VL - 14

SP - 67

EP - 74

JO - Current Opinion in Biomedical Engineering

JF - Current Opinion in Biomedical Engineering

ER -

Biomaterial strategies for creating in vitro astrocyte cultures resembling in vivo astrocyte morphologies and phenotypes

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this