Abstract
Statement of Purpose: Inflammatory arthritis (IA) is a degenerative joint disease commonly associated with chronic inflammation and subsequent cartilage damage. The pro-inflammatory and catabolic cytokines secreted by inflamed chondrocytes and macrophages are the major factors in progressing IA. Alleviating the inflammation through local delivery of therapeutics, although effective, is limited by short intra-articular half-lives. We have developed gelatin-based injectable microspheres (µSP) that exhibits degradation and drug delivery controlled by the proteolytic enzymes typically expressed during IA flares. Since the drug delivery is dependent on the disease activity, the µSP will prolong the therapeutic effect and the residence time of the drugs.
| Original language | English |
|---|---|
| Title of host publication | Society for Biomaterials Annual Meeting and Exposition 2019 |
| Subtitle of host publication | The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting |
| Pages | 709 |
| Number of pages | 1 |
| ISBN (Electronic) | 9781510883901 |
| State | Published - 2019 |
| Event | 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States Duration: Apr 3 2019 → Apr 6 2019 |
Publication series
| Name | Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium |
|---|---|
| Volume | 40 |
| ISSN (Print) | 1526-7547 |
Conference
| Conference | 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence |
|---|---|
| Country/Territory | United States |
| City | Seattle |
| Period | 4/3/19 → 4/6/19 |
Bibliographical note
Publisher Copyright:© 2019 Omnipress - All rights reserved.
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Biotechnology
- Biomaterials
- Materials Chemistry