TY - GEN
T1 - Bioresponsive microspheres for on-demand delivery of anti-inflammatory cytokines for inflammatory arthritis
AU - Park, Eunjae
AU - Hart, Melanie
AU - Rolauffs, Bernd
AU - Stegemann, Jan P.
AU - Annamalai, Ramkumar T.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: Inflammatory arthritis (IA) is a degenerative joint disease commonly associated with chronic inflammation and subsequent cartilage damage. The pro-inflammatory and catabolic cytokines secreted by inflamed chondrocytes and macrophages are the major factors in progressing IA. Alleviating the inflammation through local delivery of therapeutics, although effective, is limited by short intra-articular half-lives. We have developed gelatin-based injectable microspheres (µSP) that exhibits degradation and drug delivery controlled by the proteolytic enzymes typically expressed during IA flares. Since the drug delivery is dependent on the disease activity, the µSP will prolong the therapeutic effect and the residence time of the drugs.
AB - Statement of Purpose: Inflammatory arthritis (IA) is a degenerative joint disease commonly associated with chronic inflammation and subsequent cartilage damage. The pro-inflammatory and catabolic cytokines secreted by inflamed chondrocytes and macrophages are the major factors in progressing IA. Alleviating the inflammation through local delivery of therapeutics, although effective, is limited by short intra-articular half-lives. We have developed gelatin-based injectable microspheres (µSP) that exhibits degradation and drug delivery controlled by the proteolytic enzymes typically expressed during IA flares. Since the drug delivery is dependent on the disease activity, the µSP will prolong the therapeutic effect and the residence time of the drugs.
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M3 - Conference contribution
AN - SCOPUS:85065432444
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 709
BT - Society for Biomaterials Annual Meeting and Exposition 2019
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -