Biosyntheses of Novel Emycins from the Mutant Strain Streptomyces cellulosae ssp. griseoincarnatus 1114‐2

Martin Gerlitz; Györgyi Udarnoki; Jürgen Rohr

doi:10.1002/anie.199516171

Biosyntheses of Novel Emycins from the Mutant Strain Streptomyces cellulosae ssp. griseoincarnatus 1114‐2

Martin Gerlitz, Györgyi Udarnoki, Jürgen Rohr

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Natural products such as 1 with unprecedented molecular frameworks are produced by the mutant 1114‐2 of Streptomyces cellulosae ssp. griseoincarnatus (FH‐S 1114). Biosynthetic investigations on this genetically modified strain show that the changes at the molecular level are caused mainly by the influence of an oxygenase. Moreover, an unusual rearrangement is also involved in the generation of the product palette. (Figure Presented.)

Original language	English
Pages (from-to)	1617-1621
Number of pages	5
Journal	Angewandte Chemie International Edition in English
Volume	34
Issue number	15
DOIs	https://doi.org/10.1002/anie.199516171
State	Published - Aug 18 1995

Keywords

antibiotics
biosynthesis
oxidoreductases
polyketides
rearrangements

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.199516171

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abstract = "Natural products such as 1 with unprecedented molecular frameworks are produced by the mutant 1114‐2 of Streptomyces cellulosae ssp. griseoincarnatus (FH‐S 1114). Biosynthetic investigations on this genetically modified strain show that the changes at the molecular level are caused mainly by the influence of an oxygenase. Moreover, an unusual rearrangement is also involved in the generation of the product palette. (Figure Presented.)",

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AU - Rohr, Jürgen

PY - 1995/8/18

Y1 - 1995/8/18

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AB - Natural products such as 1 with unprecedented molecular frameworks are produced by the mutant 1114‐2 of Streptomyces cellulosae ssp. griseoincarnatus (FH‐S 1114). Biosynthetic investigations on this genetically modified strain show that the changes at the molecular level are caused mainly by the influence of an oxygenase. Moreover, an unusual rearrangement is also involved in the generation of the product palette. (Figure Presented.)

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KW - biosynthesis

KW - oxidoreductases

KW - polyketides

KW - rearrangements

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Biosyntheses of Novel Emycins from the Mutant Strain Streptomyces cellulosae ssp. griseoincarnatus 1114‐2

Abstract

Keywords

ASJC Scopus subject areas

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