Biosynthesis of enediyne antitumor antibiotics

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88 Scopus citations

Abstract

The enediyne polyketides are secondary metabolites isolated from a variety of Actinomycetes. All members share very potent anticancer and antibiotic activity, and prospects for the clinical application of the enediynes has been validated with the recent marketing of two enediyne derivatives as anticancer agents. The biosynthesis of these compounds is of interest because of the numerous structural features that are unique to the enediyne family. The gene cluster for five enediynes has now been cloned and sequenced, providing the foundation to understand natures' means to biosynthesize such complex, exotic molecules. Presented here is a review of the current progress in delineating the biosynthesis of the enediynes with an emphasis on the model enediyne, C-1027.

Original languageEnglish
Pages (from-to)448-459
Number of pages12
JournalCurrent Topics in Medicinal Chemistry
Volume8
Issue number6
DOIs
StatePublished - Apr 2008

Keywords

  • Anticancer antibiotic
  • Biosynthesis
  • C-1027
  • Enediynes
  • Maduropeptin
  • Neocarzinostatin
  • Polyketide synthase

ASJC Scopus subject areas

  • Drug Discovery

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