Biosynthetic Investigations on Pyridazomycin

Heike Bockholt; John M. Beale; Jürgen Rohr

doi:10.1002/anie.199416481

Biosynthetic Investigations on Pyridazomycin

Heike Bockholt, John M. Beale, Jürgen Rohr

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

An unexpected amino acid metabolism is used by a subspecies of the soil bacterium Streptomyces violaceoniger to produce the antifungal antibiotic pyridazomycin 1‐C1. Feeding studies with isotopically labeled precursors indicate that 1 is constructed from ornithine, glycine, and probably oxaloacetate. (Figure Presented.)

Original language	English
Pages (from-to)	1648-1651
Number of pages	4
Journal	Angewandte Chemie International Edition in English
Volume	33
Issue number	15-16
DOIs	https://doi.org/10.1002/anie.199416481
State	Published - Sep 2 1994

ASJC Scopus subject areas

Catalysis
General Chemistry

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title = "Biosynthetic Investigations on Pyridazomycin",

abstract = "An unexpected amino acid metabolism is used by a subspecies of the soil bacterium Streptomyces violaceoniger to produce the antifungal antibiotic pyridazomycin 1‐C1. Feeding studies with isotopically labeled precursors indicate that 1 is constructed from ornithine, glycine, and probably oxaloacetate. (Figure Presented.)",

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AU - Beale, John M.

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N2 - An unexpected amino acid metabolism is used by a subspecies of the soil bacterium Streptomyces violaceoniger to produce the antifungal antibiotic pyridazomycin 1‐C1. Feeding studies with isotopically labeled precursors indicate that 1 is constructed from ornithine, glycine, and probably oxaloacetate. (Figure Presented.)

AB - An unexpected amino acid metabolism is used by a subspecies of the soil bacterium Streptomyces violaceoniger to produce the antifungal antibiotic pyridazomycin 1‐C1. Feeding studies with isotopically labeled precursors indicate that 1 is constructed from ornithine, glycine, and probably oxaloacetate. (Figure Presented.)

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M3 - Article

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SN - 0570-0833

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JO - Angewandte Chemie International Edition in English

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ER -

Biosynthetic Investigations on Pyridazomycin

Abstract

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