Biosynthetic Origin of the Oxygen Atoms of Tetracenomycin C

Györgyi Udvarnoki, Christina Wagner, Reinhard Machinek, Jürgen Rohr

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Water and not acetate is the source of the oxygen atom 4a‐OH in the biosynthesis of tetracenomycin C. Based on this unusual finding, an intermediate epoxide is postulated, which has to be “cis opened” to attain the required stereochemistry at C‐4a and C‐12a (see reaction sequence below). (Figure Presented.)

Original languageEnglish
Pages (from-to)565-567
Number of pages3
JournalAngewandte Chemie International Edition in English
Issue number5
StatePublished - Mar 20 1995


  • biosynthesis
  • natural products
  • tetracenomycin C

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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