TY - JOUR
T1 - Biotinylated N,N'-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK)
AU - Sviripa, Vitaliy
AU - Conroy, Michael D.
AU - Zhang, Wen
AU - Liu, Alice
AU - Watt, David S.
PY - 2013
Y1 - 2013
N2 - Biotinylated analogs of drug candidates provide useful tools for studying the drug-target protein interactions. Polyhalogenated N,N'diarylureas are potent activators of adenosine monophosphate-activated kinase (AMPK) and potentially promising agents for the treatment of cancer. Various biotinylated versions of these N,N'-diarylureas were synthesized and evaluated in AMPK-activation studies.
AB - Biotinylated analogs of drug candidates provide useful tools for studying the drug-target protein interactions. Polyhalogenated N,N'diarylureas are potent activators of adenosine monophosphate-activated kinase (AMPK) and potentially promising agents for the treatment of cancer. Various biotinylated versions of these N,N'-diarylureas were synthesized and evaluated in AMPK-activation studies.
KW - Adenosine monophosphate-activated kinase
KW - Biotinylated N,N'-diarylureas
UR - http://www.scopus.com/inward/record.url?scp=84880833084&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880833084&partnerID=8YFLogxK
U2 - 10.3906/kim-1302-78
DO - 10.3906/kim-1302-78
M3 - Article
AN - SCOPUS:84880833084
SN - 1300-0527
VL - 37
SP - 473
EP - 479
JO - Turkish Journal of Chemistry
JF - Turkish Journal of Chemistry
IS - 4
ER -
