A series of bis-azaaromatic quaternary ammonium compounds containing flexible polymethylenic linkers as well as conformationally restricted linkers were evaluated for their affinity for the blood-brain barrier choline transporter (BBB-ChT). The preliminary structure-activity relationships obtained from this study suggest that incorporating a linear, conformationally restricted linker into the molecule improves affinity for the BBB-ChT.
|Number of pages||3|
|Journal||Bioorganic and Medicinal Chemistry Letters|
|State||Published - Jun 1 2010|
Bibliographical noteFunding Information:
This work was supported by the National Institute of Health foundation ( U19 DA017548 ).
- Bis-quaternary ammonium salts
- Blood-brain barrier
- Choline transporter
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry