Bitter Melon (Momordica charantia L.) supplementation has no effect on hypercholesterolemia and atherosclerosis in mice

Shayan Mohammadmoradi, Deborah A. Howatt, Hong S. Lu, Alan Daugherty, Sibu P. Saha

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Bitter melon (BM; Momordica charantia L.) has been reported to ameliorate diet-induced obesity and dyslipidemia. However, the effects of BM on atherosclerosis have not been determined. This study investigated the effects of BM diet-induced atherosclerosis in LDL receptor–deficient mice. A total of 30 female mice (aged 6–8 wk) were fed a saturated fat–enriched diet. In group 1 (n = 10), mice were fed this diet alone, whereas mice in groups 2 and 3 (n = 10/group) were fed the diet supplemented with BM either 0.1% or 1% by weight. After 12 wk, body weight, plasma cholesterol, and atherosclerotic plaque areas were analyzed. No significant differences in body weight and plasma cholesterol concentrations were observed among the groups. Also, BM supplementation did not affect atherosclerosis development. In conclusion, dietary BM has no effect on plasma cholesterol concentration and atherogenesis in hypercholesterolemic mice.

Original languageEnglish
Article numbernzaa148
JournalCurrent Developments in Nutrition
Volume4
Issue number10
DOIs
StatePublished - Oct 1 2020

Bibliographical note

Publisher Copyright:
© The Author(s) 2020.

Keywords

  • Atherosclerosis
  • Bitter melon
  • Cholesterol
  • Hypercholesterolemia
  • Momordica charantia

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Nutrition and Dietetics

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