Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function

Saeed Daneshmandi; Teresa Cassel; Penghui Lin; Richard M. Higashi; Gerburg M. Wulf; Vassiliki A. Boussiotis; Teresa W.M. Fan; Pankaj Seth

doi:10.1016/j.celrep.2021.108831

Blockade of 6-phosphogluconate dehydrogenase generates CD8⁺ effector T cells with enhanced anti-tumor function

Saeed Daneshmandi, Teresa Cassel, Penghui Lin, Richard M. Higashi, Gerburg M. Wulf, Vassiliki A. Boussiotis, Teresa W.M. Fan, Pankaj Seth

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Daneshmandi et al. show that 6-phosphogluconate dehydrogenase (6PGD) in the oxidative pentose phosphate pathway (PPP) is a modulator of CD8⁺ T cell activation and differentiation. 6PGD blockade reprograms CD8⁺ T cell metabolism to support superior effector function with higher tumoricidal activity. This metabolic checkpoint represents a key therapeutic target for cancer immunotherapies.

Original language	English
Article number	108831
Journal	Cell Reports
Volume	34
Issue number	10
DOIs	https://doi.org/10.1016/j.celrep.2021.108831
State	Published - Mar 9 2021

Bibliographical note

Publisher Copyright:
© 2021

Keywords

6PGD
effector T cells
metabolism
pentose phosphate pathway
reactive oxygen species
tumor immunotherapy

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.celrep.2021.108831

Cite this

@article{e3a1bc66cc624761bae26e1c27dfcb82,

title = "Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function",

abstract = "Daneshmandi et al. show that 6-phosphogluconate dehydrogenase (6PGD) in the oxidative pentose phosphate pathway (PPP) is a modulator of CD8+ T cell activation and differentiation. 6PGD blockade reprograms CD8+ T cell metabolism to support superior effector function with higher tumoricidal activity. This metabolic checkpoint represents a key therapeutic target for cancer immunotherapies.",

keywords = "6PGD, effector T cells, metabolism, pentose phosphate pathway, reactive oxygen species, tumor immunotherapy",

author = "Saeed Daneshmandi and Teresa Cassel and Penghui Lin and Higashi, {Richard M.} and Wulf, {Gerburg M.} and Boussiotis, {Vassiliki A.} and Fan, {Teresa W.M.} and Pankaj Seth",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = mar,

day = "9",

doi = "10.1016/j.celrep.2021.108831",

language = "English",

volume = "34",

number = "10",

}

TY - JOUR

T1 - Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function

AU - Daneshmandi, Saeed

AU - Cassel, Teresa

AU - Lin, Penghui

AU - Higashi, Richard M.

AU - Wulf, Gerburg M.

AU - Boussiotis, Vassiliki A.

AU - Fan, Teresa W.M.

AU - Seth, Pankaj

PY - 2021/3/9

Y1 - 2021/3/9

N2 - Daneshmandi et al. show that 6-phosphogluconate dehydrogenase (6PGD) in the oxidative pentose phosphate pathway (PPP) is a modulator of CD8+ T cell activation and differentiation. 6PGD blockade reprograms CD8+ T cell metabolism to support superior effector function with higher tumoricidal activity. This metabolic checkpoint represents a key therapeutic target for cancer immunotherapies.

AB - Daneshmandi et al. show that 6-phosphogluconate dehydrogenase (6PGD) in the oxidative pentose phosphate pathway (PPP) is a modulator of CD8+ T cell activation and differentiation. 6PGD blockade reprograms CD8+ T cell metabolism to support superior effector function with higher tumoricidal activity. This metabolic checkpoint represents a key therapeutic target for cancer immunotherapies.

KW - 6PGD

KW - effector T cells

KW - metabolism

KW - pentose phosphate pathway

KW - reactive oxygen species

KW - tumor immunotherapy

UR - http://www.scopus.com/inward/record.url?scp=85102107819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85102107819&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2021.108831

DO - 10.1016/j.celrep.2021.108831

M3 - Article

C2 - 33691103

AN - SCOPUS:85102107819

SN - 2211-1247

VL - 34

JO - Cell Reports

JF - Cell Reports

IS - 10

M1 - 108831

ER -