TY - JOUR
T1 - Blood Cytokine Profiles Associated with Distinct Patterns of Bronchopulmonary Dysplasia among Extremely Low Birth Weight Infants
AU - D'Angio, Carl T.
AU - Ambalavanan, Namasivayam
AU - Carlo, Waldemar A.
AU - McDonald, Scott A.
AU - Skogstrand, Kristin
AU - Hougaard, David M.
AU - Shankaran, Seetha
AU - Goldberg, Ronald N.
AU - Ehrenkranz, Richard A.
AU - Tyson, Jon E.
AU - Stoll, Barbara J.
AU - Das, Abhik
AU - Higgins, Rosemary D.
AU - Jobe, Alan H.
AU - Laptook, Abbot R.
AU - Oh, William
AU - Rubin, Lewis P.
AU - Hensman, Angelita M.
AU - Fanaroff, Avroy A.
AU - Walsh, Michele C.
AU - Newman, Nancy S.
AU - Siner, Bonnie S.
AU - Donovan, Edward F.
AU - Narendran, Vivek
AU - Alexander, Barbara
AU - Grisby, Cathy
AU - Hessling, Jody
AU - Mersmann, Marcia Worley
AU - Mincey, Holly L.
AU - Cotten, C. Michael
AU - Auten, Kathy J.
AU - Hale, Ellen C.
AU - Wright, Linda L.
AU - Yaffe, Sumner J.
AU - McClure, Elizabeth M.
AU - Poindexter, Brenda B.
AU - Lemons, James A.
AU - Appel, Diana D.
AU - Herron, Dianne E.
AU - Wilson, Leslie D.
AU - Poole, W. Kenneth
AU - Hastings, Betty K.
AU - Zaterka-Baxter, Kristin M.
AU - O'Donnell Auman, Jeanette
AU - Schaefer, Scott E.
AU - Stevenson, David K.
AU - Van Meurs, Krisa P.
AU - Ball, M. Bethany
AU - Collins, Monica V.
AU - Bada, Henrietta S.
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Objective To explore differences in blood cytokine profiles among distinct bronchopulmonary dysplasia (BPD) patterns. Study design We evaluated blood spots collected from 943 infants born at ≤1000 g and surviving to 28 days on postnatal days 1, 3, 7, 14, and 21 for 25 cytokines. Infants were assigned to the following lung disease patterns: (1) no lung disease (NLD); (2) respiratory distress syndrome without BPD; (3) classic BPD (persistent exposure to supplemental oxygen until 28 days of age); or (4) atypical BPD (period without supplemental oxygen before 28 days). Median cytokine levels for infants with BPD were compared with the IQR of results among infants with NLD. Results The distribution of enrolled infants by group was as follows: 69 (NLD), 73 (respiratory distress syndrome), 381 (classic BPD), and 160 (atypical BPD). The remaining 260 infants could not be classified because of missing data (104) or not fitting a predefined pattern (156). Median levels of 3 cytokines (elevated interleukin [IL]-8, matrix metalloproteinase-9; decreased granulocyte macrophage colony-stimulating factor) fell outside the IQR for at least 2 time points in both infants with atypical and classic BPD. Profiles of 7 cytokines (IL-6, IL-10, IL-18, macrophage inflammatory protein-1α, C-reactive protein, brain-derived neurotrophic factor, regulated on activation, normal T cell expressed and secreted) differed between infants with classic and atypical BPD. Conclusions Blood cytokine profiles may differ between infants developing classic and atypical BPD. These dissimilarities suggest the possibility that differing mechanisms could explain the varied patterns of pathophysiology of lung disease in extremely premature infants.
AB - Objective To explore differences in blood cytokine profiles among distinct bronchopulmonary dysplasia (BPD) patterns. Study design We evaluated blood spots collected from 943 infants born at ≤1000 g and surviving to 28 days on postnatal days 1, 3, 7, 14, and 21 for 25 cytokines. Infants were assigned to the following lung disease patterns: (1) no lung disease (NLD); (2) respiratory distress syndrome without BPD; (3) classic BPD (persistent exposure to supplemental oxygen until 28 days of age); or (4) atypical BPD (period without supplemental oxygen before 28 days). Median cytokine levels for infants with BPD were compared with the IQR of results among infants with NLD. Results The distribution of enrolled infants by group was as follows: 69 (NLD), 73 (respiratory distress syndrome), 381 (classic BPD), and 160 (atypical BPD). The remaining 260 infants could not be classified because of missing data (104) or not fitting a predefined pattern (156). Median levels of 3 cytokines (elevated interleukin [IL]-8, matrix metalloproteinase-9; decreased granulocyte macrophage colony-stimulating factor) fell outside the IQR for at least 2 time points in both infants with atypical and classic BPD. Profiles of 7 cytokines (IL-6, IL-10, IL-18, macrophage inflammatory protein-1α, C-reactive protein, brain-derived neurotrophic factor, regulated on activation, normal T cell expressed and secreted) differed between infants with classic and atypical BPD. Conclusions Blood cytokine profiles may differ between infants developing classic and atypical BPD. These dissimilarities suggest the possibility that differing mechanisms could explain the varied patterns of pathophysiology of lung disease in extremely premature infants.
KW - chronic lung disease
KW - inflammatory markers
KW - premature infant
KW - respiratory distress syndrome
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U2 - 10.1016/j.jpeds.2016.03.058
DO - 10.1016/j.jpeds.2016.03.058
M3 - Article
C2 - 27117196
AN - SCOPUS:84964241120
SN - 0022-3476
VL - 174
SP - 45-51.e5
JO - Journal of Pediatrics
JF - Journal of Pediatrics
ER -