Blood pressure monitoring using radio telemetry method in mice

Yu Wang, Sean E. Thatcher, Lisa A. Cassis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

9 Scopus citations

Abstract

The TA11PA-C10 implantable transmitter (Data Sciences International, DSI) is designed to measure blood pressure (BP) and activity in freely moving laboratory mice. The fluid filled catheter is placed in the free flowing blood of the systemic artery (inserted into the left carotid artery and extended into the aorta), and the transmitter body is placed in a benign location for long-term biocompatibility. The transmitter can be used to monitor BP in mice (as small as 17 g) under normal physiological and unrestricted conditions 24 h a day while remaining free from stress associated with human interaction. Thus, telemetry is considered the gold standard for BP monitoring in small animals such as mice. However, this methodology does require a good understanding of the system as well as appropriate training to perform the delicate transmitter implantation surgery.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
Pages75-85
Number of pages11
DOIs
StatePublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1614
ISSN (Print)1064-3745

Bibliographical note

Publisher Copyright:
© 2017, Springer Science+Business Media LLC.

Funding

FundersFunder number
National Heart, Lung, and Blood Institute (NHLBI)R01HL107326

    Keywords

    • Blood pressure
    • Catheter
    • Left carotid artery
    • Radio telemetry
    • Transmitter

    ASJC Scopus subject areas

    • Molecular Biology
    • Genetics

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