Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease

Hirosha Geekiyanage; Gregory A. Jicha; Peter T. Nelson; Christina Chan

doi:10.1016/j.expneurol.2011.11.026

Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease

Hirosha Geekiyanage, Gregory A. Jicha, Peter T. Nelson, Christina Chan

Research output: Contribution to journal › Article › peer-review

263 Scopus citations

Abstract

There is an urgent need to identify non-invasive biomarkers for the detection of sporadic Alzheimer's disease (AD). We previously studied microRNAs (miRNAs) in AD autopsy brain samples and reported a connection between miR-137, -181c, -9, -29a/b and AD, through the regulation of ceramides. In this study, the potential role of these miRNAs as diagnostic markers for AD was investigated. We identified that these miRNAs were down-regulated in the blood serum of probable AD patients. The levels of these miRNAs were also reduced in the serum of AD risk factor models. Although the ability of these miRNAs to conclusively diagnose for AD is currently unknown, our findings suggest a potential use for circulating miRNAs, along with other markers, as non-invasive and relatively inexpensive biomarkers for the early diagnosis of AD, however, with further research and validation.

Original language	English
Pages (from-to)	491-496
Number of pages	6
Journal	Experimental Neurology
Volume	235
Issue number	2
DOIs	https://doi.org/10.1016/j.expneurol.2011.11.026
State	Published - Jun 2012

Bibliographical note

Funding Information:
We thank the UK ADC NIA P30-AG0-28383 for providing the human blood serum samples. This work was supported in part by the National Institute of Health ( R01GM079688 , R01GM089866 and R21RR024439 ), the National Science Foundation ( CBET 0941055 and CBET 1049127 ) and the MSU Foundation .

Keywords

Alzheimer's disease
Blood serum
MicroRNA

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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10.1016/j.expneurol.2011.11.026

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title = "Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease",

abstract = "There is an urgent need to identify non-invasive biomarkers for the detection of sporadic Alzheimer's disease (AD). We previously studied microRNAs (miRNAs) in AD autopsy brain samples and reported a connection between miR-137, -181c, -9, -29a/b and AD, through the regulation of ceramides. In this study, the potential role of these miRNAs as diagnostic markers for AD was investigated. We identified that these miRNAs were down-regulated in the blood serum of probable AD patients. The levels of these miRNAs were also reduced in the serum of AD risk factor models. Although the ability of these miRNAs to conclusively diagnose for AD is currently unknown, our findings suggest a potential use for circulating miRNAs, along with other markers, as non-invasive and relatively inexpensive biomarkers for the early diagnosis of AD, however, with further research and validation.",

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author = "Hirosha Geekiyanage and Jicha, {Gregory A.} and Nelson, {Peter T.} and Christina Chan",

note = "Funding Information: We thank the UK ADC NIA P30-AG0-28383 for providing the human blood serum samples. This work was supported in part by the National Institute of Health ( R01GM079688 , R01GM089866 and R21RR024439 ), the National Science Foundation ( CBET 0941055 and CBET 1049127 ) and the MSU Foundation .",

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AU - Jicha, Gregory A.

AU - Nelson, Peter T.

AU - Chan, Christina

N1 - Funding Information: We thank the UK ADC NIA P30-AG0-28383 for providing the human blood serum samples. This work was supported in part by the National Institute of Health ( R01GM079688 , R01GM089866 and R21RR024439 ), the National Science Foundation ( CBET 0941055 and CBET 1049127 ) and the MSU Foundation .

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AB - There is an urgent need to identify non-invasive biomarkers for the detection of sporadic Alzheimer's disease (AD). We previously studied microRNAs (miRNAs) in AD autopsy brain samples and reported a connection between miR-137, -181c, -9, -29a/b and AD, through the regulation of ceramides. In this study, the potential role of these miRNAs as diagnostic markers for AD was investigated. We identified that these miRNAs were down-regulated in the blood serum of probable AD patients. The levels of these miRNAs were also reduced in the serum of AD risk factor models. Although the ability of these miRNAs to conclusively diagnose for AD is currently unknown, our findings suggest a potential use for circulating miRNAs, along with other markers, as non-invasive and relatively inexpensive biomarkers for the early diagnosis of AD, however, with further research and validation.

KW - Alzheimer's disease

KW - Blood serum

KW - MicroRNA

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Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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