Blueberry Supplementation in Midlife for Dementia Risk Reduction

Robert Krikorian, Matthew R. Skelton, Suzanne S. Summer, Marcelle D. Shidler, Patrick G. Sullivan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Late-life dementia typically develops over a period of many years beginning in midlife. Prevalence of metabolic disturbance also accelerates in middle age and is a prominent risk factor for dementia. Preliminary studies indicate that blueberry supplementation can improve cognitive performance and influence metabolism and brain function and therefore may have a role in early intervention to prevent neurodegeneration. In a randomized controlled trial, we investigated the effects of daily blueberry supplementation in a middle-aged sample of insulin-resistant participants with elevated risk for future dementia. We enrolled overweight men and women, aged 50 to 65 years, with subjective cognitive decline (SCD) and performed pre-and post-intervention assessments of cognition and metabolism and exploratory measures of peripheral mitochondrial function. We observed improved performances for the blueberry group on measures of lexical access, p = 0.003, and memory interference, p = 0.04, and blueberry-treated participants reported reduced memory encoding difficulty in daily life activities, p = 0.03. The blueberry-treated group also exhibited correction of peripheral hyperinsulinemia, p = 0.04, and a modest trend for increased mitochondrial uncoupling, p = 0.11. The cognitive findings indicated improved executive ability in this middle-aged sample. In addition, the changes in metabolic and bioenergetic measures imply potential mechanistic factors associated with anthocyanin and proanthocyanidin actions. The demonstration of these benefits in middle-aged individuals with insulin resistance and SCD suggests that ongoing blueberry supplementation may contribute to protection against cognitive decline when implemented early in at-risk individuals.

Original languageEnglish
Article number1619
JournalNutrients
Volume14
Issue number8
DOIs
StatePublished - Apr 1 2022

Bibliographical note

Funding Information:
Funding: This research was funded by the US Highbush Blueberry Council, Folsom, CA, USA. This organization also provided the blueberry powder and placebo powder research products.

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • BMI
  • cognition
  • insulin resistance

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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