TY - JOUR
T1 - Body composition assessment in spinal cord injury clinical trials
AU - Gater, David R.
AU - Clasey, Jody L.
PY - 2006/12
Y1 - 2006/12
N2 - Body weight and composition impact almost every aspect of rehabilitation and community reintegration for the person with spinal cord injury (SCI), but they have received fairly little attention from the rehabilitation community. In particular, sarcopenia (muscle wasting) and fat accumulation due to paralysis significantly impair activities of daily living, community mobility, cardiopulmonary health, bowel and bladder function, skin integrity, and spasticity and can contribute to morbidities associated with obesity including atherosclerosis, diabetes, dyslipidemia, hypertension, chronic pain, depression, and societal isolation. Usual methods of body composition assessment typically underestimate body fat in SCI and are relatively insensitive to changes that may occur from exercise and nutritional interventions. Current body composition assessment techniques are reviewed for their appropriateness in use with the SCI population, and limitations of those techniques are discussed. Recommendations are made for future investigations to validate clinical assessment tools with the 4-compartment (gold standard) model of body composition assessment and for minimal standards of reporting body weight and composition in clinical trials.
AB - Body weight and composition impact almost every aspect of rehabilitation and community reintegration for the person with spinal cord injury (SCI), but they have received fairly little attention from the rehabilitation community. In particular, sarcopenia (muscle wasting) and fat accumulation due to paralysis significantly impair activities of daily living, community mobility, cardiopulmonary health, bowel and bladder function, skin integrity, and spasticity and can contribute to morbidities associated with obesity including atherosclerosis, diabetes, dyslipidemia, hypertension, chronic pain, depression, and societal isolation. Usual methods of body composition assessment typically underestimate body fat in SCI and are relatively insensitive to changes that may occur from exercise and nutritional interventions. Current body composition assessment techniques are reviewed for their appropriateness in use with the SCI population, and limitations of those techniques are discussed. Recommendations are made for future investigations to validate clinical assessment tools with the 4-compartment (gold standard) model of body composition assessment and for minimal standards of reporting body weight and composition in clinical trials.
KW - Body composition
KW - Body fat
KW - Exercise
KW - Obesity
KW - Spinal cord injury
UR - http://www.scopus.com/inward/record.url?scp=30344478242&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=30344478242&partnerID=8YFLogxK
U2 - 10.1310/6P99-QKEB-EQ7J-CYY9
DO - 10.1310/6P99-QKEB-EQ7J-CYY9
M3 - Review article
AN - SCOPUS:30344478242
SN - 1082-0744
VL - 11
SP - 36
EP - 49
JO - Topics in Spinal Cord Injury Rehabilitation
JF - Topics in Spinal Cord Injury Rehabilitation
IS - 3
ER -