Body Fluid microRNAs as Toxicological Biomarkers

Zhishan Wang, Chengfeng Yang

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

This chapter discusses the history, biogenesis and functions for microRNAs (miRNAs). The miRNA expression profiles of human cancer tissues have been shown to be very informative, reflecting signatures associated with cancer diagnosis, progression, response to treatment and final prognosis. These findings highlight the potential of profiling miRNA expressions as biomarkers for cancer diagnosis. Due to the exceptional stability and non-invasive nature of body fluid miRNAs, a subsequent large numbers of studies have now shown that body fluid miRNAs could be used as promising novel biomarkers for the detection of cancer and other diseases, and for assessing early responses to toxicant or drug exposures. The potential usefulness of serum miRNAs as diagnostic biomarkers for drug- and liver transplantation caused liver injuries has been explored in recent human studies. Identifying reliable and non-invasive biomarkers for early diagnosis of heart injuries remains one of the major challenges in cardiovascular research.

Original languageEnglish
Title of host publicationmicroRNAs in Toxicology and Medicine
Pages343-364
Number of pages22
ISBN (Electronic)9781118695999
DOIs
StatePublished - Sep 9 2013

Keywords

  • Biomarkers
  • Body fluid miRNAs
  • MiRNA expressions
  • Toxicant exposures

ASJC Scopus subject areas

  • Chemistry (all)
  • Chemical Engineering (all)

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